Mode of Action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and Human Relevance
Mode of Action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and Human Relevance
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DOI：
10.1016/j.reprotox.2011.10.014
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发表时间：
2012-07-01
影响因子：
3.3
通讯作者：
Kamendulis, Lisa M.
中科院分区：
文献类型：
--
作者：
Klaunig, James E.;Hocevar, Barbara A.;Kamendulis, Lisa M.
Perfluorooctanoic acid (PFOA) is an environmentally persistent chemical used in the manufacturing of a wide array of industrial and commercial products. PFOA has been shown to induce tumors of the liver, testis and pancreas (tumor triad) in rats following chronic dietary administration. PFOA belongs to a group of compounds that are known to activate the PPAR alpha receptor. The PPAR alpha activation Mode of Action was initially addressed in 2003[9]and further refined in subsequent reviews [92-94]. In the intervening time, additional information on PFOA effects as well as a further refinement of the Mode of Action framework warrants a re-examination of this compound for its cancer induction Mode of Action. This review will address the rodent (rat) cancer data and cancer Mode of Action of PFOA for tumors of the liver, testes and pancreas. (C) 2011 Elsevier Inc. All rights reserved.
