Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation.
Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation.
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DOI：
10.1016/j.biochi.2010.02.008
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发表时间：
2010-06
期刊：
影响因子：
3.9
通讯作者：
Obeid, Lina M.
中科院分区：
文献类型：
--
作者：
Snider, Ashley J.;Gandy, K. Alexa Orr;Obeid, Lina M.
鞘磷脂及其合成酶是炎症反应的重要介质，也是免疫细胞功能的调节因子。尤其是鞘氨醇激酶(SK)及其产物鞘氨醇-1-磷酸(S1P)被广泛地参与了这些过程。SK催化鞘氨醇磷酸化为S1P，以SK1和SK2两种亚型存在。细胞因子包括肿瘤坏死因子-α和白细胞介素1-β(IL1-β)可激活SK1。在这一途径中，SK1的激活至少部分地是介导细胞内肿瘤坏死因子-α和白介素1-β炎症反应所必需的，包括诱导环氧合酶-2(COX-2)。除了在炎症信号转导中发挥作用外，SK和S1P还参与多种免疫细胞功能，包括肥大细胞脱颗粒、中性粒细胞迁移、淋巴细胞迁移和成熟。鞘脂和鞘脂代谢酶参与炎症信号和免疫细胞功能，这些介质也参与了许多炎症疾病状态。本文讨论了这些介质，特别是SK1和S1P在炎症和疾病中的作用。
Sphingolipids and their synthetic enzymes are emerging as important mediators in inflammatory responses and as regulators of immune cell functions. In particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P) have been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. SK1 has been shown to be activated by cytokines including tumor necrosis factor-alpha (TNF-α) and interleukin1-β (IL1-β). The activation of SK1 in this pathway has been shown to be, at least in part, required for mediating TNF-α and IL1-β inflammatory responses in cells, including induction of cyclo-oxygenase 2 (COX-2). In addition to their role in inflammatory signaling, SK and S1P have also been implicated in various immune cell functions including, mast cell degranulation, migration of neutrophils, and migration and maturation of lymphocytes. The involvement of sphingolipids and sphingolipid metabolizing enzymes in inflammatory signaling and immune cell functions has implicated these mediators in numerous inflammatory disease states as well. The contribution of these mediators, specifically SK1 and S1P, to inflammation and disease are discussed in this review.
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DOI：
10.1126/science.1176709
发表时间：
2009-09-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hait NC;Allegood J;Maceyka M;Strub GM;Harikumar KB;Singh SK;Luo C;Marmorstein R;Kordula T;Milstien S;Spiegel S
通讯作者：
Spiegel S
DOI：
10.1152/ajpheart.01101.2003
发表时间：
2004-10-01
影响因子：
4.8
作者：
Chen, XL;Grey, JY;Kunsch, C
通讯作者：
Kunsch, C
DOI：
10.1016/j.bbalip.2003.11.006
发表时间：
2004-02-27
影响因子：
4.8
作者：
Fukuda, Y;Aoyama, Y;Igarashi, Y
通讯作者：
Igarashi, Y
影响因子：
4.8
作者：
Billich, A;Bornancin, F;Baumruker, T
通讯作者：
Baumruker, T
影响因子：
4.8
作者：
Allende, ML;Sasaki, T;Proia, RL
通讯作者：
Proia, RL