Antinociceptive effects of tramadol and acepromazine in cats
Antinociceptive effects of tramadol and acepromazine in cats
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DOI：
10.1016/j.jfms.2007.06.009
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发表时间：
2008-02
影响因子：
1.7
通讯作者：
P. Steagall;P. Taylor;J. Brondani;S. Luna;M. Dixon
中科院分区：
文献类型：
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作者：
P. Steagall;P. Taylor;J. Brondani;S. Luna;M. Dixon
在8只猫上研究了曲马多和乙酰丙嗪对压力和热阈值的影响。基线测量后，皮下（SC）给予曲马多1 mg/kg、乙酰丙嗪0.1 mg/kg、曲马多1 mg/kg+乙酰丙嗪0.1 mg/kg或生理盐水0.3 ml。连续测量24小时。平均热阈值与基线相比无显著变化[方差分析（ANOVA）]。曲马多给药后6 h，热阈值较基线升高的最大值为2.8±2.8°C（P>0.05）;在0.75、3和6 h，热阈值高于95%置信区间（CI）。在乙酰丙嗪治疗后0.25 ~ 2 h（P<0.05）和联合治疗后0.5 ~ 3 h（P<0.05），压力阈值高于基线，在乙酰丙嗪治疗后0.25h和联合治疗后0.5h最大增加132±156 mmHg和197±129 mmHg。乙酰丙嗪给药后0.25 - 2 h和联合给药后0.5 - 3 h，压力阈值高于95% CI。SC曲马多在1毫克/公斤的猫有有限的影响，热和压力伤害性，但这是增强乙酰丙嗪。单独使用乙酰丙嗪具有压力镇痛作用。
Effects of tramadol and acepromazine on pressure and thermal thresholds were examined in eight cats. After baseline measurements, subcutaneous (SC) tramadol 1 mg/kg, acepromazine 0.1 mg/kg, tramadol 1 mg/kg with acepromazine 0.1 mg/kg, or saline 0.3 ml were given. Serial measurements were made for 24 h. Mean thermal thresholds did not change significantly [analysis of variance (ANOVA)] from baseline. The maximum thermal threshold increase above baseline was 2.8±2.8°C at 6 h (P>0.05) after tramadol; it was above the 95% confidence interval (CI) at 0.75, 3 and 6 h. Pressure thresholds increased above baseline from 0.25 to 2 h after acepromazine (P<0.05) and from 0.5 to 3 h after the combination (P<0.05), with a maximum increase of 132±156 mmHg 0.25 h after acepromazine and 197±129 mmHg 0.5 h after the combination. Pressure thresholds were above the 95% CI from 0.25 to 2 h after acepromazine and from 0.5 to 3 h after the combination. SC tramadol at 1 mg/kg in cats had limited effect on thermal and pressure nociception, but this was enhanced by acepromazine. Acepromazine alone had pressure antinociceptive effects.