Older adults exhibit a more pronounced modulation of beta oscillations when performing sustained and dynamic handgrips.
Older adults exhibit a more pronounced modulation of beta oscillations when performing sustained and dynamic handgrips.
复制标题
老年人在进行持续和动态的握力时表现出更明显的β振荡调节。
DOI：
10.1016/j.neuroimage.2019.116037
复制
发表时间：
2019
期刊：
影响因子：
5.7
通讯作者：
Boudrias,Marie-Hélène
中科院分区：
文献类型：
--
作者：
Xifra-Porxas,Alba;Niso,Guiomar;Larivière,Sara;Kassinopoulos,Michalis;Baillet,Sylvain;Mitsis,GeorgiosD;Boudrias,Marie-Hélène
肌肉收缩与β振荡活动的减少有关，称为运动相关β去同步（MRBD）。与年轻人相比，老年人的MRBD表现出更大的振幅，尽管他们在休息和肌肉收缩时的β能量仍然更高。此外，在持续的和动态的捏缩期间，MRBD的调节被观察到，在动态收缩之后的稳定收缩期间，β活性升高。然而，MRBD的调节如何受到年龄的影响仍然是一个悬而未决的问题。在目前的工作中，我们研究了老化对β振荡调制的影响及其与运动性能的假定联系。我们收集了年轻人和老年人在静息状态和运动握力模式下的脑磁图（MEG）数据，其中包括持续和动态收缩，以量化自发和运动相关的β振荡活动。在老年人的运动皮层中，静止时的β能量被发现显著增加。在动态手部收缩期间，MRBD在老年参与者的额叶、运动前和运动脑区域更为明显。这些大脑区域也表现出与年龄相关的皮层厚度下降；然而，在控制年龄后，发现MRBD的大小和皮质厚度没有关联。在持续的手部收缩期间，两组的MRBD表现出与动态收缩期相比的幅度下降，并且没有显示出与年龄相关的差异。这表明，与年轻人相比，老年人MRBD在动态收缩和持续收缩之间的幅度变化更大。我们进一步探索了β振荡和运动行为之间的关系，发现初级运动皮层中较大的MRBD与年龄后运动性能下降有关，但我们的结果表明，β振荡与年龄相关的差异并不能预测运动性能。
Muscle contractions are associated with a decrease in beta oscillatory activity, known as movement-related beta desynchronization (MRBD). Older adults exhibit a MRBD of greater amplitude compared to their younger counterparts, even though their beta power remains higher both at rest and during muscle contractions. Further, a modulation in MRBD has been observed during sustained and dynamic pinch contractions, whereby beta activity during periods of steady contraction following a dynamic contraction is elevated. However, how the modulation of MRBD is affected by aging has remained an open question. In the present work, we investigated the effect of aging on the modulation of beta oscillations and their putative link with motor performance. We collected magnetoencephalography (MEG) data from younger and older adults during a resting-state period and motor handgrip paradigms, which included sustained and dynamic contractions, to quantify spontaneous and motor-related beta oscillatory activity. Beta power at rest was found to be significantly increased in the motor cortex of older adults. During dynamic hand contractions, MRBD was more pronounced in older participants in frontal, premotor and motor brain regions. These brain areas also exhibited age-related decreases in cortical thickness; however, the magnitude of MRBD and cortical thickness were not found to be associated after controlling for age. During sustained hand contractions, MRBD exhibited a decrease in magnitude compared to dynamic contraction periods in both groups and did not show age-related differences. This suggests that the amplitude change in MRBD between dynamic and sustained contractions is larger in older compared to younger adults. We further probed for a relationship between beta oscillations and motor behaviour and found that greater MRBD in primary motor cortices was related to degraded motor performance beyond age, but our results suggested that age-related differences in beta oscillations were not predictive of motor performance.