Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis.
Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis.
复制标题
炎性关节炎发病机制中的肌腱和韧带机械负荷。
DOI：
10.1038/s41584-019-0364-x
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发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
Elewaut D
中科院分区：
文献类型：
--
作者：
Gracey E;Burssens A;Cambré I;Schett G;Lories R;McInnes IB;Asahara H;Elewaut D
机械负荷是影响肌肉骨骼健康和疾病的重要因素。肌腱和韧带需要生理水平的机械负荷来发展和维持其组织结构，这一过程是通过力学转导介导的肌腱和韧带基质细胞对细胞外基质的微调在细胞水平上实现的。病理水平的力代表一种生物(机械)应激，它在肌腱和韧带中引发免疫系统介导的组织修复途径。肌腱和韧带的生物力学和机械生物学形成了了解这些组织如何感知和响应机械力的基础，一些与机械应力相关的肌腱和韧带疾病在解剖学上与慢性炎症性关节炎影响的关节重叠。机械压力在肌腱病等过度使用损伤中的作用早已为人所知，但机械压力现在也可能成为某些形式的慢性炎症性关节炎的触发因素，包括脊柱性关节炎和类风湿性关节炎。因此，看似不同的肌肉骨骼系统疾病可能具有相似的免疫病理机制，这是由于对机械应力的保守反应。
Mechanical loading is an important factor in musculoskeletal health and disease. Tendons and ligaments require physiological levels of mechanical loading to develop and maintain their tissue architecture, a process that is achieved at the cellular level through mechanotransduction-mediated fine tuning of the extracellular matrix by tendon and ligament stromal cells. Pathological levels of force represent a biological (mechanical) stress that elicits an immune system-mediated tissue repair pathway in tendons and ligaments. The biomechanics and mechanobiology of tendons and ligaments form the basis for understanding how such tissues sense and respond to mechanical force, and several mechanical stress-related tendon and ligament disorders overlap anatomically with joints affected by chronic inflammatory arthritis. The role of mechanical stress in ‘overuse’ injuries, such as tendinopathy, has long been known, but mechanical stress is now also emerging as a possible trigger for some forms of chronic inflammatory arthritis, including spondyloarthritis and rheumatoid arthritis. Thus, seemingly diverse diseases of the musculoskeletal system might have similar mechanisms of immunopathogenesis owing to conserved responses to mechanical stress.
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影响因子：
27.4
作者：
Baeten D;Østergaard M;Wei JC;Sieper J;Järvinen P;Tam LS;Salvarani C;Kim TH;Solinger A;Datsenko Y;Pamulapati C;Visvanathan S;Hall DB;Aslanyan S;Scholl P;Padula SJ
通讯作者：
Padula SJ
影响因子：
4.1
作者：
Chen L;Kim PD;Ahmad CS;Levine WN
通讯作者：
Levine WN
DOI：
10.1084/jem.20070906
发表时间：
2008-02-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Armaka M;Apostolaki M;Jacques P;Kontoyiannis DL;Elewaut D;Kollias G
通讯作者：
Kollias G
影响因子：
27.4
作者：
Bridgewood, Charlie;Watad, Abdulla;McGonagle, Dennis G.
通讯作者：
McGonagle, Dennis G.
DOI：
10.1177/107110078500600202
发表时间：
1985-01-01
期刊：
FOOT & ANKLE
影响因子：
--
作者：
ATTARIAN, DE;MCCRACKIN, HJ;GARRETT, WE
通讯作者：
GARRETT, WE