Increased level of apolipoprotein B/apolipoprotein A1 ratio as a potential risk for osteonecrosis
Increased level of apolipoprotein B/apolipoprotein A1 ratio as a potential risk for osteonecrosis
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DOI：
10.1136/ard.58.8.514
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发表时间：
1999-08-01
影响因子：
27.4
通讯作者：
Iwamoto, Y
中科院分区：
文献类型：
--
作者：
Miyanishi, K;Yamamoto, T;Iwamoto, Y
本研究旨在研究载脂蛋白B与载脂蛋白A1的高比例是否（apo B/apo A1比率）与发生非创伤性股骨头坏死（ON）的风险显著相关。方法将50例连续的非创伤性ON病例与50例年龄和性别匹配的对照进行比较，使用单变量和逐步判别分析，关于皮质类固醇的因素，酒精、香烟、胆固醇、甘油三酯和载脂蛋白B/载脂蛋白A1比值。为了排除ON或骨关节炎改变本身可增加apo B/apo A1比值的可能性，结果：高载脂蛋白B/载脂蛋白A1比值与非创伤性ON的发生有显著相关性，单因素分析显示，高载脂蛋白B/载脂蛋白A1比值与非创伤性ON的发生有显著相关性，而高载脂蛋白B/载脂蛋白A1比值与非创伤性ON的发生无显著相关性。（p=0.0001）和逐步判别分析（部分r（2）=0.1239，p=0.0004）。非创伤性ON组apo B/apo A1比值显著高于创伤性ON组（p
Objective-This study was performed to investigate whether a high ratio of apolipoprotein B to apolipoprotein A1 (apo B/apo A1 ratio) is significantly associated with the risk of developing non-traumatic osteonecrosis of the femoral head (ON).Methods-Fifty consecutive nontraumatic ON cases were compared with 50 age and sex matched controls, using both univariate and stepwise discriminant analyses, regarding the factors of corticosteroid, alcohol, cigarettes, cholesterol, triglyceride, and apo B/apo A1 ratio. To eliminate the possibility that ON or osteoarthritic change itself can increase the apo B/apo A1 ratio, a further 32 consecutive cases comprising nine traumatic ON and 23 osteoarthritis (OA) patients were analysed using Scheffe's test.Results-There was a significant association between a high apo B/apo A1 ratio and the development of non-traumatic ON with both univariate (p=0.0001) and stepwise discriminant analyses (partial r(2)=0.1239, p=0.0004). The apo B/apo A1 ratio in the non-traumatic ON group was significantly higher than that in the traumatic ON (p