Leishmanicidal phenolic compounds derived from Dalbergia cultrata
Leishmanicidal phenolic compounds derived from Dalbergia cultrata
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源自 Dalbergia cultrata 的杀利什曼酚类化合物
DOI：
10.1080/14786419.2020.1744140
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发表时间：
2020
影响因子：
2.2
通讯作者：
Sekita Setsuko
中科院分区：
文献类型：
--
作者：
Mori-Yasumoto Kanami;Hashimoto Yukihiro;Agatsuma Yutaka;Fuchino Hiroyuki;Yasumoto Ko;Shirota Osamu;Satake Motoyoshi;Sekita Setsuko
利什曼病是一种热带原生动物感染，据估计全世界每年新增病例超过30万例。从黄檀木材中分离得到一个新的酚类化合物cultratin A(1)，其中包括3个已知的新黄烷素(2，3，4)，2个苯并呋喃(5，6)和2个酚类化合物(7，8)。用波谱方法确定了它们的结构。其中，新化合物(1)和4-(S)-甲氧基达尔贝酮(2)具有较强的杀利什曼活性(IC_(50)分别为2.0和2.6 μM)，化合物8具有中等活性(IC_(50)：11 μM)。化合物1和2的细胞毒性也弱于其他化合物。
Leishmaniasis is a protozoan tropical infection that is estimated to be more than 0.3 million new cases occur annually worldwide. A novel phenolic compound, cultratin A (1), was isolated as a leishmanicidal constituent from the timber ofDalbergia cultrata,along with three known neoflavanoids (2,3,4), two benzofurans (5,6), and two phenolic compounds (7,8). Their structures were determined using spectral methods. Among them, a new compound (1) and 4-(S)-methoxydalbergione (2) showed effective leishmanicidal activities (IC50: 2.0 and 2.6 μM, respectively), while compound8showed moderate activity (IC50: 11 μM). The cytotoxicity of compounds1and2was also weaker than that of the other compounds.