CORRELATION OF C3 LEVEL WITH SEVERITY OF GENERALIZED MYASTHENIA GRAVIS
CORRELATION OF C3 LEVEL WITH SEVERITY OF GENERALIZED MYASTHENIA GRAVIS
复制标题
C3 水平与全身性重症肌无力严重程度的相关性
DOI：
10.1002/mus.21398
复制
发表时间：
2009-11-01
期刊：
影响因子：
3.4
通讯作者：
Li, Zhuyi
中科院分区：
文献类型：
--
作者：
Liu, Aidong;Lin, Hong;Li, Zhuyi
全身性重症肌无力(GMG)急性加重可导致吞咽障碍、呼吸衰竭或死亡。重要的是确定免疫学因素，这些因素可能被可靠地视为患者的临床状况、治疗反应和某些免疫异常的测量指标。在这项研究中，我们研究了补体成分C3、乙酰胆碱受体抗体(AChRab)效价与GMG临床严重程度的相关性。用放射免疫法和散射比浊法分别测定AChRab滴度和C3浓度。根据Besinger和他的同事的说法，GMG的临床严重性是通过定量MG评分(QMGS)来评估的。我们的研究结果表明，C3水平与AChRab阳性GMG的临床严重程度相关。肌肉神经40：801-808,2009
Acute exacerbation of generalized myasthenia gravis (GMG) can cause swallowing impairment, respiratory failure, or death. It is important to identify immunological factors that might be regarded reliably as an index of the patient's clinical condition, response to treatment, and measure of certain immune aberrations of MG. In this study we investigated correlations between complement component C3, acetylcholine receptor antibody (AChRab) titer, and clinical severity of GMG. AChRab titer and C3 concentration were determined by radioimmunoassay and nephelometry, respectively. The clinical severity of GMG was assessed by the quantitative MG score (QMGS) according to Besinger and colleagues. Our findings indicate that the C3 level correlates with clinical severity of AChRab-positive GMG. Muscle Nerve 40:801-808, 2009