MODULATION OF RHYTHMIC FUNCTION IN THE POSTERIOR MIDBRAIN
MODULATION OF RHYTHMIC FUNCTION IN THE POSTERIOR MIDBRAIN
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DOI：
10.1016/0306-4522(88)90295-3
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发表时间：
1988-11-01
期刊：
影响因子：
3.3
通讯作者：
SKINNER, RD
中科院分区：
文献类型：
--
作者：
GARCIARILL, F;SKINNER, RD
在“虚构自发运动”准备中记录猫中脑后部的单个单位活动。神经元的活动进行了研究的发病，交替和终止的周期后肢神经造影活动的前丘-后乳头横断动物。组织化学鉴定pedunculopontine（烟酰胺腺嘌呤二核苷酸磷酸-心肌黄酶阳性）神经元允许本地化的记录网站在这个核。位于楔状核背侧的脚桥核的区域中的神经元被发现优先与周期性（爆裂）的神经活动，而脚桥核的区域中的神经元被发现优先与周期性发作的开始（“开”）或终止（“关”）相关。该区域不同的细胞群似乎与周期性发作（开/关）的持续时间相比，与交替（爆发）的频率有关。虽然楔形脚桥核的面积已被发现相当于中脑运动区，但同一区域已被发现与其他节律活动（例如呼吸，咀嚼，睡眠周期，加压，膀胱运动等）有关。一个假设，提出了占的重量的证据暗示同一地区在主机的不同的节奏活动。这一假设表明，胆碱能（脚桥，背侧被盖核）和胺能（蓝斑，黑质）中心之间的振荡混响是负责产生各种功能相关的“频率”（爆发）或“状态”（开/关）的活动。
Recordings of single unit activity in the posterior midbrain of the cat were carried out in the "fictive spontaneous locomotion" preparation. Neuronal activity was studied in relation to the onset, alternation and termination of cyclic hindlimb neurographic activity in the precollicular-postmammillary transected animal. Histochemical identification of pedunculopontine (nicotinamide adenine dinuceotide phosphate-diaphorase positive) neurons allowed the localization of recording sites in relation to this nucleus. Neurons located in the area of the cuneiform nucleus dorsal to the pedunculopontine nucleus were found to be related preferentially to cyclic (bursting) neurographic activity, while neurons in the area of the pedunculopontine were found to be related preferentially to the onset ("on") or termination ("off") of cycling episodes. Different populations of cells in the area appeared to be related to the frequency of alternation (bursting) compared with the duration of the cyclic episodes (on/off). While the area of the cuneiform-pedunculopontine nucleus has been found to be equivalent to the mesencephalic locomotor region, the same area has been found to be related to other rhythmic activities (e.g. respiratory, masticatory, sleep cycle, pressor, vesico-motor, etc.). A hypothesis is proposed to account for the weight of evidence implicating the same region in a host of distinct rhythmic activities. This hypothesis suggest that an oscillatory reverberation between cholinergic (pedunculopontine, laterodorsal tegmental nuclei) and aminergic (locus coeruleus, substantia nigra) centers is responsible for generating the various function-related "frequencies" (bursting) or "states" (on/off) of activity.