Multiple organ failure: inflammatory priming and activation sequences promote autologous tissue injury.
Multiple organ failure: inflammatory priming and activation sequences promote autologous tissue injury.
复制标题
多器官衰竭：炎症引发和激活序列促进自体组织损伤。
DOI：
10.1097/00005373-199012001-00012
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
A. Harken
中科院分区：
文献类型：
--
作者：
Benjamin O. Anderson;A. Harken
Systemic inflammation promotes multiple organ failure through the induction of diffuse microvascular leak. Inflammatory cells such as neutrophils propagate this process. Tissue injury by neutrophils may be viewed as a normal process, inflammation, that has become uncontrolled and generalized. Multiple inflammatory stimuli synergistically promote neutrophil-mediated tissue injury in priming and activation sequences. In some settings, cellular priming is mediated by platelet-activating factor and can be prevented by platelet-activating factor antagonists. Inhibiting cellular priming could be efficacious in the therapy of multiple organ failure.
