The left amygdala knows fear: laterality in the amygdala response to fearful eyes
The left amygdala knows fear: laterality in the amygdala response to fearful eyes
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DOI：
10.1093/scan/nsn001
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发表时间：
2008-03-01
影响因子：
4.2
通讯作者：
Puce, Aina
中科院分区：
文献类型：
--
作者：
Hardee, Jillian E.;Thompson, James C.;Puce, Aina
杏仁核在检测威胁方面发挥了很好的作用，这一点在人类神经成像研究中得到了证实。恐惧脸的一个关键因素是眼白色区域（EWA）的增加，假设这是激活杏仁核的重要线索。然而，另一个可以增加EWA的重要社会信号是注视方向的横向转移，这也有助于将注意力导向潜在的威胁。目前还不清楚杏仁核如何区分EWA的增加和那些与恐惧有关的增加。使用功能性磁共振成像，我们发现，左杏仁核区分恐惧的眼睛和目光转移，尽管类似的EWA增加，而右杏仁核是歧视性的。进一步的分析也显示了选择性半球反应模式在左梭状回。我们的数据显示，在基于EWA的恐惧激活中存在明显的半球差异，这表明存在着编码情感面孔信息的并行机制。
The detection of threat is a role that the amygdala plays well, evidenced by its increased response to fearful faces in human neuroimaging studies. A critical element of the fearful face is an increase in eye white area (EWA), hypothesized to be a significant cue in activating the amygdala. However, another important social signal that can increase EWA is a lateral shift in gaze direction, which also serves to orient attention to potential threats. It is unknown how the amygdala differentiates between these increases in EWA and those that are specifically associated with fear. Using functional magnetic resonance imaging, we show that the left amygdala distinguished between fearful eyes and gaze shifts despite similar EWA increases whereas the right amygdala was less discriminatory. Additional analyses also revealed selective hemispheric response patterns in the left fusiform gyrus. Our data show clear hemispheric differences in EWA-based fear activation, suggesting the existence of parallel mechanisms that code for emotional face information.