Relation of sleep-disordered breathing to cardiovascular disease risk factors - The Sleep Heart Health Study
Relation of sleep-disordered breathing to cardiovascular disease risk factors - The Sleep Heart Health Study
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DOI：
10.1093/aje/154.1.50
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发表时间：
2001-07-01
影响因子：
5
通讯作者：
Quan, SF
中科院分区：
文献类型：
--
作者：
Newman, AB;Nieto, FJ;Quan, SF
睡眠呼吸障碍和心血管疾病（CVD）之间的关联可能是由睡眠呼吸障碍患者较高的心血管危险因素水平介导的。作者在1995年10月至1998年2月进行的睡眠心脏健康研究中检查了这些关系，该研究是一项由6，440名年龄超过40岁的男性和女性组成的多种族队列，其特征是家庭多导睡眠图。在睡眠研究时没有自我报告的CVD的4，991名参与者中，中等水平的睡眠呼吸障碍是常见的，中位呼吸紊乱指数（RDI）为4.0（四分位数范围，1.25-10.7）。RDI水平与年龄、体重指数、腰臀比、高血压、糖尿病和血脂水平呈横断面相关。这些关系在65岁以下的人中比在65岁以上的人中更为明显。RDI在高四分位数的65岁以下女性比RDI相似的男性更肥胖。尽管这种关联模式与RDI较高的人肥胖程度较高一致，但较高的体重指数并不能解释所有这些关联。如果在未来的随访中显示睡眠呼吸障碍会增加CVD事件的风险，部分风险可能是由于RDI较高的患者的心血管风险因素较高。
Associations between sleep-disordered breathing and cardiovascular disease (CVD) may be mediated by higher cardiovascular risk factor levels in those with sleep-disordered breathing. The authors examined these relations in the Sleep Heart Health Study, a multiethnic cohort of 6,440 men and women over age 40 years conducted from October 1995 to February 1998 and characterized by home polysomnography. In 4,991 participants who were free of self-reported CVD at the time of the sleep study, moderate levels of sleep-disordered breathing were common, with a median Respiratory Disturbance Index (RDI) of 4.0 (interquartile range, 1.25-10.7). The level of RDI was associated cross-sectionally with age, body mass index, waist-to-hip ratio, hypertension, diabetes, and lipid levels. These relations were more pronounced in those under age 65 years than in those over age 65. Women under age 65 years with RDI in the higher quartiles were more obese than men with similar RDI. Although the pattern of associations was consistent with greater obesity in those with higher RDI, higher body mass index did not explain all of these associations. If sleep-disordered breathing is shown in future follow-up to increase the risk for incident CVD events, part of the risk is likely to be due to the higher cardiovascular risk factors in those with higher RDI.