Early age conductive hearing loss causes audiogenic seizure and hyperacusis behavior.
Early age conductive hearing loss causes audiogenic seizure and hyperacusis behavior.
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DOI：
10.1016/j.heares.2011.08.004
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发表时间：
2011-12
期刊：
影响因子：
2.8
通讯作者：
Allman B
中科院分区：
文献类型：
--
作者：
Sun W;Manohar S;Jayaram A;Kumaraguru A;Fu Q;Li J;Allman B
最近的临床报告发现，在患有听觉过敏的儿童中，复发性中耳炎的发病率很高，这是一种对普通环境声音的明显不耐受。然而，目前尚不清楚早期中耳炎引起的传导性听力损失是否会影响以后的生活中的声音耐受力。因此，我们已经测试了鼓膜（TM）损伤的影响，在早期的声音知觉发展的大鼠。TM穿孔后2周，80%以上的大鼠在暴露于强噪声（120 dB SPL白色噪声，< 1分钟）时出现听源性癫痫发作（AGS）。AGS的易感性在TM损伤后至少持续16周，即使听力损失也能恢复。TM损伤大鼠也表现出显着增强的声惊吓反应相比，大鼠没有TM损伤。这些结果表明，早期传导性听力损失可能会导致发育过程中的声音耐受性受损。此外，AGS可以通过氨己烯酸治疗来抑制，急性注射（250 mg/kg）或口服摄入（60 mg/kg/天，持续7天），这是一种抑制GABA的catalysis的抗癫痫药物。c-Fos染色显示，在TM损伤大鼠的下丘（IC），而不是在对照组大鼠，暴露于响亮的声音，表明在AGS过程中的IC的高兴奋性。这些结果表明，早期传导性听力损失可以通过减少IC中的GABA抑制来损害声音耐受性，这可能与中耳炎儿童中观察到的听觉过敏有关。
Recent clinical reports found a high incidence of recurrent otitis media in children suffering hyperacusis, a marked intolerance to an otherwise ordinary environmental sound. However, it is unclear whether the conductive hearing loss caused by otitis media in early age will affect sound tolerance later in life. Thus, we have tested the effects of tympanic membrane (TM) damage at an early age on sound perception development in rats. Two weeks after the TM perforation, more than 80% of the rats showed audiogenic seizure (AGS) when exposed to loud sound (120 dB SPL white noise, < 1 minute). The susceptibility of AGS lasted at least sixteen weeks after the TM damage, even the hearing loss recovered. The TM damaged rats also showed significantly enhanced acoustic startle responses compared to the rats without TM damage. These results suggest that early age conductive hearing loss may cause an impaired sound tolerance during development. In addition, the AGS can be suppressed by the treatment of vigabatrin, acute injections (250 mg/kg) or oral intakes (60 mg/kg/day for 7 days), an antiepileptic drug that inhibits the catabolism of GABA. c-Fos staining showed a strong staining in the inferior colliculus (IC) in the TM damaged rats, not in the control rats, after exposed to loud sound, indicating a hyper-excitability in the IC during AGS. These results indicate that early age conductive hearing loss can impair sound tolerance by reducing GABA inhibition in the IC, which may be related to hyperacusis seen in children with otitis media.