T-helper 1/T-helper 2 cytokine imbalance and clinical phenotypes of acute-phase major depression
T-helper 1/T-helper 2 cytokine imbalance and clinical phenotypes of acute-phase major depression
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DOI：
10.1111/j.1440-1819.2007.01686.x
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发表时间：
2007-08-01
影响因子：
11.9
通讯作者：
Lee, Chien-Te
中科院分区：
文献类型：
--
作者：
Huang, Tiao-Lai;Lee, Chien-Te
一些研究讨论了辅助性T细胞1（Th 1）或Th 2细胞因子与抑郁症的关系。本研究旨在探讨Th 1/Th 2细胞因子平衡与抑郁症急性期临床表型的关系。共招募了82名受试者，包括42名重性抑郁障碍患者和40名健康对照。检测白细胞介素-1 β（IL-1 β）、肿瘤坏死因子-α（TNF-α）和IL-10的血清细胞因子水平。使用年龄和体重指数（BMI）调整的ancova，在重度抑郁症患者和健康对照组之间血清IL-1 β，TNF-α和IL-10水平没有显着差异。然而，使用仅调整BMI的ancova，结果显示，重度抑郁症患者的TNF-α水平显著高于对照组。此外，使用经年龄和BMI调整的ancova，观察到具有胆固醇特征的患者的血清IL-1 β水平和IL-1 β/IL-10比值显著高于具有非胆固醇特征的患者。然而，有和无自杀企图的患者之间的血清IL-1 β，TNF-α和IL-10水平没有显著差异。结论：血清TNF-α、IL-1 β水平及IL-1 β/IL-10比值在急性期抑郁症的发病机制中起重要作用。
Several studies have discussed the relationships between T-helper 1 (Th1) or Th2 cytokines and major depression. The aim of the present study was to investigate the relationships between Th1/Th2 cytokine balance and clinical phenotypes of acute-phase major depression. A total of 82 subjects including 42 patients with major depressive disorder and 40 healthy controls were recruited. Serum cytokine levels of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha) and IL-10 were examined. Using ancova with age and body mass index (BMI) adjustments, there were no significant differences in serum IL-1 beta, TNF-alpha, and IL-10 levels between patients with major depressive disorder and healthy controls. However, using ancova with BMI adjustment only, the results showed that patients with major depressive disorder had significantly higher TNF-alpha levels than control subjects. In addition, using ancova with age and BMI adjustments, significantly higher serum IL-1 beta level and IL-1 beta/IL-10 ratio were noted in patients with melancholic features than patients with non-melancholic features. However, there were no significant differences in serum IL-1 beta, TNF-alpha and IL-10 levels between patients with and without suicide attempt. In conclusion, serum TNF-alpha, IL-1 beta level and IL-1 beta/IL-10 ratio might play an important role in the psychopathology of acute-phase major depressive disorder.