Embryonic beginnings of definitive hematopoietic stem cells
Embryonic beginnings of definitive hematopoietic stem cells
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DOI：
10.1111/j.1749-6632.1999.tb08470.x
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Dzierzak, E
中科院分区：
文献类型：
--
作者：
Dzierzak, E
成人血液系统中多种类型的细胞从造血细胞中不断补充和更新的能力。干细胞是发育和分化中的一个有趣的问题，并导致了一些问题，如这些成人造血系统的干细胞是如何、何时和在哪里在胚胎中产生的，在胚胎发育期间，许多成熟的造血细胞出现在成人型造血细胞之前：干细胞，因此传统的造血层次结构的概念受到了挑战。探索小鼠胚胎中造血干细胞发育的实验有力地表明，在发育过程中，至少有两个独立的造血细胞部位产生血细胞；产生瞬时胚胎造血系统的卵黄SAD区域和启动长寿成人造血系统的AGM(主动脉-性腺-中肾)区域。
The ability of the many cell types within the adult blood system to be constantly replenished and renewed from hematopoietic. stem cells is an interesting problem in development and differentiation and has led to questions concerning how, when and where these stem cells for the adult hematopoietic system are generated within the embryo, During embryonic development many mature hematopoietic cells appear before adult-type hematopoietic: stem cells thus the notion of a conventional hematopoietic hierarchy is challenged. Experiments probing the development of hematopoietic stem cells in the mouse embryo strongly suggest that at least two independent hematopoietic sites generate blood cells during development; the yolk sad, which produces the transient embryonic hematopoietic system, and the AGM (aorta-gonad-mesonephros) region, which initiates the long-lived adult hematopoietic system.