Artemisinin for treatment of uncomplicated falciparum malaria: Is there a place for monotherapy?
Artemisinin for treatment of uncomplicated falciparum malaria: Is there a place for monotherapy?
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DOI：
10.4269/ajtmh.2001.65.690
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发表时间：
2001-12-01
影响因子：
3.3
通讯作者：
De Vries, PJ
中科院分区：
文献类型：
--
作者：
Giao, PT;Binh, TQ;De Vries, PJ
在227例无并发症恶性疟疾患者中研究了青蒿素单药治疗的疗效。他们都在t = 0小时，t = 8小时接受青蒿素，此后每天一次;治疗随机延长，直到他们服用青蒿素5天，随后服用安慰剂2天（A5）或青蒿素7天（A7）。成人青蒿素剂量为500毫克;
The efficacy of artemisinin monotherapy was studied in 227 patients with uncomplicated falciparum malaria. They all received artemisinin at t = 0 hr, t = 8 hr, and thereafter once daily; treatment was extended at random until they had taken either 5 days of artemisinin followed by 2 days of placebo (A5), or 7 days (A7) of artemisinin. The adult artemisinin dose was 500 mg; children aged