Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production.
Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production.
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DOI：
10.1152/physrev.00031.2007
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发表时间：
2008-10
影响因子：
33.6
通讯作者：
Jackson MJ
中科院分区：
文献类型：
--
作者：
Powers SK;Jackson MJ
1978年首次提出体育锻炼会导致自由基介导的组织损伤，在过去的三十年里，人们对锻炼和氧化应激的认识有了很大的增长。尽管运动中产生氧化剂的来源仍然存在争议，但现在已经确定的是，休息和收缩骨骼肌都会产生活性氧和活性氮。重要的是，高强度和长时间的运动会对收缩的心肌细胞中的蛋白质和脂质造成氧化损伤。此外，氧化剂还可以调节多种细胞信号通路，调节真核细胞中多个基因的表达。这种由氧化剂介导的基因表达变化涉及转录、信使核糖核酸稳定性和信号转导水平的变化。此外，大量与氧化调节基因相关的产物已被鉴定，包括抗氧化酶、应激蛋白、DNA修复蛋白和线粒体电子传输蛋白。有趣的是，低水平和生理水平的活性氧是骨骼肌正常力量产生所必需的，但高水平的活性氧会促进收缩功能障碍，导致肌肉无力和疲劳。正在进行的研究继续探索氧化剂影响骨骼肌收缩特性的机制，并探索能够保护肌肉免受氧化剂介导的功能障碍的干预措施。
The first suggestion that physical exercise results in free radical-mediated damage to tissues appeared in 1978, and the past three decades have resulted in a large growth of knowledge regarding exercise and oxidative stress. Although the sources of oxidant production during exercise continue to be debated, it is now well established that both resting and contracting skeletal muscles produce reactive oxygen species and reactive nitrogen species. Importantly, intense and prolonged exercise can result in oxidative damage to both proteins and lipids in the contracting myocytes. Furthermore, oxidants can modulate a number of cell signaling pathways and regulate the expression of multiple genes in eukaryotic cells. This oxidant-mediated change in gene expression involves changes at transcriptional, mRNA stability, and signal transduction levels. Furthermore, numerous products associated with oxidant-modulated genes have been identified and include antioxidant enzymes, stress proteins, DNA repair proteins, and mitochondrial electron transport proteins. Interestingly, low and physiological levels of reactive oxygen species are required for normal force production in skeletal muscle, but high levels of reactive oxygen species promote contractile dysfunction resulting in muscle weakness and fatigue. Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction.
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DOI：
10.1519/00124278-200311000-00028
发表时间：
2003-11-01
影响因子：
3.2
作者：
Avery, NG;Kaiser, JL;Volek, JS
通讯作者：
Volek, JS
DOI：
10.1016/s1095-6433(97)00421-2
发表时间：
1998-01-01
影响因子：
2.3
作者：
Abraham, RZ;Kobzik, L;Stamler, JS
通讯作者：
Stamler, JS
影响因子：
5.5
作者：
Andrade, FH;Reid, MB;Westerblad, H
通讯作者：
Westerblad, H
影响因子：
5.5
作者：
Adhihetty, PJ;Ljubicic, V;Hood, DA
通讯作者：
Hood, DA
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P