Mechanisms linking obesity to insulin resistance and type 2 diabetes
Mechanisms linking obesity to insulin resistance and type 2 diabetes
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DOI：
10.1038/nature05482
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发表时间：
2006-12-14
期刊：
影响因子：
64.8
通讯作者：
Utzschneider, Kristina M.
中科院分区：
文献类型：
--
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
肥胖与胰岛素抵抗和2型糖尿病的风险增加有关。在肥胖个体中，脂肪组织释放出更多的非酯化脂肪酸、甘油、激素、促炎细胞因子和其他参与胰岛素抵抗发展的因素。当胰岛素抵抗伴有胰岛β细胞功能障碍时，释放胰岛素的细胞无法控制血糖水平。因此，β细胞功能的异常对于确定2型糖尿病的风险和发展至关重要。这一知识正在促进对这种疾病的分子和遗传基础以及治疗和预防这种疾病的新方法的探索。
Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, proinflammatory cytokines and other factors that are involved in the development of insulin resistance. When insulin resistance is accompanied by dysfunction of pancreatic islet beta-cells - the cells that release insulin failure to control blood glucose levels results. Abnormalities in beta-cell function are therefore critical in defining the risk and development of type 2 diabetes. This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention.