The effects of ethanol on the transport of β-estradiol and other permeants in hairless mouse skin. II. A new quantitative approach☆
The effects of ethanol on the transport of β-estradiol and other permeants in hairless mouse skin. II. A new quantitative approach☆
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乙醇对无毛小鼠皮肤中β-雌二醇和其他渗透物转运的影响II。
DOI：
10.1016/0168-3659(87)90065-4
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发表时间：
1987
影响因子：
10.8
通讯作者：
W. Good
中科院分区：
文献类型：
--
作者：
A. Ghanem;H. Mahmoud;W. Higuchi;U. Rohr;S. Borsadia;Puchun Liu;J. Fox;W. Good
在0-100%乙醇/生理盐水浓度范围内，研究了乙醇对β-雌二醇和其他渗透物在无毛小鼠皮肤中的转运行为的影响。在高乙醇水平（bbb50 %）下，皮肤角质层成分的新孔形成显著增加。对于纯乙醇，无论极性如何，孔隙途径运输主导了所有溶质的渗透。在低乙醇水平（<25%）时，乙醇对孔隙途径的影响很小或没有影响。而β-雌二醇和氢化可的松通过角质层脂质途径的转运则大大增强。β-雌二醇和氢化可的松的增强因子E是通过对真皮/表皮渗透系数、角质层孔隙通路渗透系数进行校正，并利用溶解度数据对化学势随溶剂组成的变化进行校正，根据实验渗透数据计算得到的。发现β-雌二醇和氢化可的松的e值具有相同的数量级（25%乙醇为7 ~ 9,50%乙醇为100数量级）。有人提出，在低乙醇水平下的乙醇增强效应可以解释为运输速率限制脂质结构域的流动性增加。
The influence of ethanol on the transport behavior of β-estradiol and other permeants in hairless mouse skin was investigated over a 0–100% ethanol/saline concentration range. At high ethanol levels (> 50%), there were significant increases in new pore formation in the stratum corneum component of the skin. With pure ethanol, pore pathway transport dominated the permeation for all solutes, irrespective of polarity. At low ethanol levels (<25%), ethanol had little or no effect on the pore pathway. However, the transport of β-estradiol and hydrocortisone via the lipid pathway of the stratum corneum was greatly enhanced. The enhancement factor, E, for β-estradiol and for hydrocortison was calculated from the experimental permeation data by correcting for the dermis /epidermis permeability coefficient, the stratum corneum pore pathway permeability coefficient, and by using solubility data to correct for chemical potential changes with solvent composition. The E-values for β-estradiol and for hydrocortisone were found to be of the same magnitude (7 to 9 at 25% ethanol and of the order of 100 at 50% ethanol). It is proposed that the ethanol enhancement effects at low ethanol levels may be interpreted in terms of fluidity increases in the transport rate-limiting lipid domains.
载体对水杨酸通过无毛小鼠皮肤扩散的影响。
影响因子：
3.8
作者：
Sloan,KB;Siver,KG;Koch,SA
通讯作者：
Koch,SA
酒精中毒与一系列短链醇引起的脑膜紊乱之间的关系。
DOI：
--
发表时间：
1981
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Lyon,RC;McComb,JA;Schreurs,J;Goldstein,DB
通讯作者：
Goldstein,DB