Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women
Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women
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DOI：
10.1192/bjp.175.4.351
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发表时间：
1999-10-01
影响因子：
10.5
通讯作者：
Neale, MC
中科院分区：
文献类型：
--
作者：
Kendler, KS;Karkowski, LM;Neale, MC
背景后，最初暴露于使用的精神活性物质，精神活性物质使用障碍（PSUD;）可能会或可能不会development.Aims调查的风险因素之间的关系，启动和随后的滥用精神活性substances.Method非法物质的使用和滥用的一生的历史是通过电话采访获得的1934名成员的女性-女性双胞胎对。我们应用一种新的模型，估计的作用，影响启动和特定的滥用，三类非法精神活性物质的遗传和环境的风险因素，以个人特定的环境和家庭环境影响的概率启动，但只有个人特定的环境有影响的概率随后的滥用。遗传因素影响的风险启动和missions.Conclusions影响药物启动和随后的误用相关，但不相同的病因因素。家庭环境是药物试验风险的重要决定因素。两类遗传风险因素对PSUD的易感性起作用：影响启动概率的因素和影响滥用风险的因素。利益声明由美国国立药物滥用和精神卫生研究院支持。
Background Subsequent to initial exposure to the use of a psychoactive substance, psychoactive substance use disorder (PSUD;) may or may not develop.Aims To investigate the relationship between the risk factors for initiation and the subsequent misuse of psychoactive substances.Method The lifetime history of illicit substance use and misuse was obtained by telephone interview with 1934 members of female-female twin pairs. We apply a novel model, which estimates the role of genetic and environmental risk factors that influence initiation and those specific to misuse, to three classes of illicit psychoactive substances.Results The individual-specific environment and family environment influenced the probability of initiation, but only individual-specific environment had an impact on the probability of subsequent misuse. Genetic factors which influence the risk of initiation and of misuse were identified.Conclusions Aetiological factors that influence drug initiation and subsequent misuse are correlated but not identical. Family environment is an important determinant of risk fdr drug experimentation. Two classes of genetic risk factors act on the liability to PSUD: those that influence the probability of initiation and those that influence the risk of misuse.Declaration of interest Supported by the US National Institutes of Drug Abuse and Mental Health.