Effects of constant light exposure on allergic and irritant contact dermatitis in mice reared under constant light conditions
Effects of constant light exposure on allergic and irritant contact dermatitis in mice reared under constant light conditions
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恒定光照对恒定光照条件下饲养的小鼠过敏性和刺激性接触性皮炎的影响
DOI：
10.1111/exd.14308
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Katoh N.
中科院分区：
文献类型：
--
作者：
2.Mizutani H;Tamagawa-Mineoka R;Yasuike R;Minami Y;Yagita K;Katoh N.
环境光照水平会影响生理功能，如一般活动、体温和新陈代谢。不规律的生活方式，如夜间暴露在光线下，会加剧几种炎症性皮肤病的临床症状。然而，持续光照对免疫反应的影响尚未完全了解。本研究旨在阐明持续光照对两种主要类型皮肤反应（过敏性接触性皮炎（ACD）和刺激性接触性皮炎（ICD））的影响。将BALB/c小鼠保持在恒定光照条件或正常光照和黑暗周期下，分别在耳皮肤局部应用2，4，6-三硝基-1-氯苯和巴豆油后评估其ACD和ICD反应。有趣的是，在ACD和ICD中，耳肿胀反应和局部白细胞浸润因持续暴露于光而加重，这之前已被证明会严重干扰小鼠的行为节律。在ACD中，这些发现伴随着脱颗粒肥大细胞和嗜酸性粒细胞数量的增加。这些结果表明，持续的光照会加剧过敏性和非过敏性皮肤炎症。
Environmental light levels can affect physiological functions, such as general activity, body temperature and metabolism. Irregular lifestyles, such as those involving exposure to light during the night, can exacerbate the clinical symptoms of several inflammatory skin diseases. However, the effects of constant light exposure on immune responses are not fully understood. This study aimed to elucidate the effects of constant light exposure on two major types of skin reactions, allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). BALB/c mice were kept under constant light conditions or a normal light and dark cycle, and their ACD and ICD responses were assessed after the topical application of 2,4,6‐trinitro‐1‐chlorobenzene and croton oil, respectively, to the ear skin. Interestingly, in both ACD and ICD, the ear‐swelling response and local leukocyte infiltration were aggravated by constant exposure to light, which has previously been shown to severely disturb the behavioural rhythms of mice. In ACD, these findings were accompanied by increases in the numbers of degranulated mast cells and eosinophils. These results suggest that constant light exposure intensifies allergic and non‐allergic skin inflammation.