Enantioselective synthesis of (2S,3R)-3-hydroxy-3-methylproline, a novel amino acid found in polyoxypeptins.
Enantioselective synthesis of (2S,3R)-3-hydroxy-3-methylproline, a novel amino acid found in polyoxypeptins.
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(2S,3R)-3-羟基-3-甲基脯氨酸（聚氧肽素中发现的一种新型氨基酸）的对映选择性合成。
DOI：
10.1021/jo016227
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Z. Yao
中科院分区：
文献类型：
--
作者：
Dongguang Qin;Huiyan Zha;Z. Yao
通过Sharpless AD反应、NaN（3）区域选择性开环和分子内关环反应，实现了（2S，3R）-3-羟基-3-甲基脯氨酸（3）的对映选择性合成。报道的路线具有较高的总收率和良好的对映体纯度的优点，以及从容易获得的化学底物和廉价的试剂。
The enantioselective synthesis of (2S,3R)-3-hydroxy-3-methylproline (3) was achieved by the Sharpless AD, regioselective opening of cyclic sulfate by NaN(3) and intramolecular ring-closing reaction. The reported route has the advantage of a high overall yield and good enantiomeric purity, as well as starting from readily available chemical substrates and inexpensive reagents.