Effect of vitamin D supplementation on the level of circulating high-sensitivity C-reactive protein: a meta-analysis of randomized controlled trials.
Effect of vitamin D supplementation on the level of circulating high-sensitivity C-reactive protein: a meta-analysis of randomized controlled trials.
复制标题
补充维生素 D 对循环高敏 C 反应蛋白水平的影响：随机对照试验的荟萃分析
DOI：
10.3390/nu6062206
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发表时间：
2014-06-10
期刊：
影响因子：
5.9
通讯作者：
Qin LQ
中科院分区：
文献类型：
--
作者：
Chen N;Wan Z;Han SF;Li BY;Zhang ZL;Qin LQ
维生素D可能通过降低循环中高敏C反应蛋白（hs-CRP）（一种炎症标志物）的水平，对心血管疾病产生保护作用。因此，我们对随机对照试验进行了荟萃分析，以评估维生素D补充与循环hs-CRP水平的相关性。2013年9月通过PubMed、Web of Science和科克伦图书馆进行了系统性文献检索（2014年2月更新），以识别合格研究。使用固定效应或随机效应模型计算合并效应。对10项试验（共924名参与者）的荟萃分析结果显示，补充维生素D可显著降低循环hs-CRP水平1.08 mg/L（95% CI，-2.13，-0.03），具有异质性证据。亚组分析表明，基线hs-CRP水平≥5 mg/L的受试者中降幅更大，为2.21 mg/L（95% CI，−3.50，−0.92）。Meta回归分析进一步显示，基线hs-CRP水平、维生素D补充剂量和干预持续时间可能共同导致研究间的异质性。总之，补充维生素D有利于降低循环hs-CRP。然而，由于存在异质性的证据，因此应谨慎解释结果。
Vitamin D might elicit protective effects against cardiovascular disease by decreasing the level of circulating high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker. Thus, we conducted a meta-analysis of randomized controlled trials to evaluate the association of vitamin D supplementation with circulating hs-CRP level. A systematic literature search was conducted in September 2013 (updated in February 2014) via PubMed, Web of Science, and Cochrane library to identify eligible studies. Either a fixed-effects or a random-effects model was used to calculate pooled effects. The results of the meta-analysis of 10 trials involving a total of 924 participants showed that vitamin D supplementation significantly decreased the circulating hs-CRP level by 1.08 mg/L (95% CI, −2.13, −0.03), with the evidence of heterogeneity. Subgroup analysis suggested a higher reduction of 2.21 mg/L (95% CI, −3.50, −0.92) among participants with baseline hs-CRP level ≥5 mg/L. Meta-regression analysis further revealed that baseline hs-CRP level, supplemental dose of vitamin D and intervention duration together may be attributed to the heterogeneity across studies. In summary, vitamin D supplementation is beneficial for the reduction of circulating hs-CRP. However, the result should be interpreted with caution because of the evidence of heterogeneity.