CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells
CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells
复制标题
CO2 气体诱导 pH 敏感脂质体释放药物以规避阿霉素耐药细胞
DOI：
10.1039/c2cc31697h
复制
发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Liang, Xing-Jie
中科院分区：
文献类型：
--
作者：
Liu, Juan;Ma, Huili;Liang, Xing-Jie
采用NH4HCO3梯度法制备了一种新型pH敏感的阿霉素脂质体。脂质体能够在 pH 5.0 时通过产生 CO2 气体释放药物。更重要的是，载药脂质体有效规避了乳腺癌细胞对阿霉素的耐药性。
A novel pH-sensitive liposome encapsulating doxorubicin was prepared by a NH4HCO3 gradient method. The liposomes were able to release the drug at pH 5.0 by the production of CO2 gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin.