Superficially located enlarged lymphoid follicles characterise nodular gastritis
Superficially located enlarged lymphoid follicles characterise nodular gastritis
复制标题
DOI：
10.1097/pat.0000000000000195
复制
发表时间：
2015-01-01
期刊：
影响因子：
4.5
通讯作者：
Kobayashi, Motohiro
中科院分区：
文献类型：
--
作者：
Okamura, Takuma;Sakai, Yasuhiro;Kobayashi, Motohiro
结节性胃炎是影响胃窦的慢性幽门螺杆菌胃炎的一种形式，内镜下的特征是存在类似鸡皮疙瘩的小结节性病变。人们普遍认为，淋巴滤泡增生是结节性胃炎的组织学特征；然而，支持这一假设的定量分析尚未见报道。我们的目标是确定结节性胃炎是否以淋巴滤泡增生为特征。确定结节性胃炎中淋巴滤泡的数量、大小和位置，并将这些特性与萎缩性胃炎样本进行比较。还评估了高内皮微静脉（HEV）样血管的百分比。结节性胃炎和萎缩性胃炎的淋巴滤泡数量相当；然而，结节性胃炎的滤泡大小明显大于萎缩性胃炎。此外，结节性胃炎的淋巴滤泡比萎缩性胃炎的淋巴滤泡位置更浅。与萎缩性胃炎相比，结节性胃炎中鸡皮肉样病变区域的 MECA-79(+) HEV 样血管百分比更高。位于表层的增生性淋巴滤泡是结节性胃炎的特征，这些滤泡对应于内镜下观察到的鸡皮疙瘩样结节性病变。这些观察结果表明，MECA-79(+) HEV 样血管在结节性胃炎的发病机制中至少发挥部分作用。
Nodular gastritis is a form of chronic Helicobacter pylori gastritis affecting the gastric antrum and characterised endoscopically by the presence of small nodular lesions resembling gooseflesh. It is generally accepted that hyperplasia of lymphoid follicles histologically characterises nodular gastritis; however, quantitative analysis in support of this hypothesis has not been reported. Our goal was to determine whether nodular gastritis is characterised by lymphoid follicle hyperplasia. The number, size, and location of lymphoid follicles in nodular gastritis were determined and those properties compared to samples of atrophic gastritis. The percentages of high endothelial venule (HEV)-like vessels were also evaluated. The number of lymphoid follicles was comparable between nodular and atrophic gastritis; however, follicle size in nodular gastritis was significantly greater than that seen in atrophic gastritis. Moreover, lymphoid follicles in nodular gastritis were positioned more superficially than were those in atrophic gastritis. The percentage of MECA-79(+) HEV-like vessels was greater in areas with gooseflesh-like lesions in nodular versus atrophic gastritis. Superficially located hyperplastic lymphoid follicles characterise nodular gastritis, and these follicles correspond to gooseflesh-like nodular lesions observed endoscopically. These observations suggest that MECA-79(+) HEV-like vessels could play at least a partial role in the pathogenesis of nodular gastritis.