Intra- and extra-familial influences on alcohol and drug misuse: a twin study of gene-environment correlation
Intra- and extra-familial influences on alcohol and drug misuse: a twin study of gene-environment correlation
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DOI：
10.1046/j.1360-0443.2001.969130710.x
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发表时间：
2001-09-01
期刊：
影响因子：
6
通讯作者：
Wolf, H
中科院分区：
文献类型：
--
作者：
Jang, KL;Vernon, PA;Wolf, H
目标。基因型-环境相关性是指个体暴露于环境的程度作为其遗传倾向的函数。这些相关性在精神病理学研究中很重要，因为它们识别出可能维持疾病潜在遗传倾向表达的环境。本研究探讨了酒精和药物滥用的遗传倾向与对原生家庭和课堂社会环境的看法之间的相关性。设计。邮政调查数据是从同卵双胞胎和异卵双胞胎中收集的。环境。通过报纸广告和媒体故事从加拿大不列颠哥伦比亚省温哥华招募双胞胎。参与者。从普通人群中招募了 85 对同卵双胞胎和 77 对异卵双胞胎。测量方面，双胞胎完成了人格病理学维度评估、家庭环境量表、课堂环境量表和创伤事件问卷中包含的酒精和药物滥用的自我报告测量。发现。基因索引的酒精和药物滥用评分在环境索引的 FES 和 CES 量表上进行回归。结论是，酗酒和滥用药物的遗传倾向与家庭道德宗教重点、家庭凝聚力和课堂任务导向的感知减弱以及对课堂秩序和组织（严格性）的感知增强相关。基因型-环境相关性，特别是家庭中的道德-宗教重点，似乎在药物滥用的发展中很重要。
Aims. Genotype-environment correlation refers to the extent to which individuals are exposed to environments as a function of their genetic propensities. These correlations are important in the study of psychopathology because they identify environments that may maintain the expression of underlying genetic liabilities for a disorder. The present study examined the correlation between genetic liabilities for alcohol and drug misuse with perceptions of the social environments of the family of origin and the classroom. Design. Postal survey data were collected from monozygotic and dizygotic twin pairs. Setting. Twin pairs were recruited from Vancouver, British Columbia, Canada using newspaper advertisements and media stories. Participants. Eighty-five monozygotic and 77 dizygotic twin pairs were recruited from the general population. Measurements, Twin pairs completed self-report measures of alcohol and drug misuse contained in the Dimensional Assessment of Personality Pathology, the Family Environment Scale, the Classroom Environment Scale, and the Traumatic Events Questionnaire. Findings. Genetically indexed alcohol and drug misuse scores were regressed on the environmentally indexed FES and CES scales. Genetic liabilities for alcohol and drug misuse were associated with decreased perceived family moral-religious emphases, family cohesion and classroom task orientation and increased perceptions of classroom order and organization (strictness), Conclusions. Genotype-environment correlations, in particular, moral-religious emphases in the home, appear to be important in the development of substance misuse.