Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma
Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma
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作者：
Rosen, DG;Yang, G;Liu, JS
背景细胞周期蛋白、细胞周期蛋白依赖性激酶（cdks）及其抑制剂联合作用调节细胞周期进程，在癌中经常失调。作者推测细胞周期蛋白E在卵巢癌的发生中起重要作用，其过表达可能是预后不良的指标。方法：应用组织芯片技术，通过图像分析对正常卵巢、囊腺瘤、低恶性潜能肿瘤和405例原发性卵巢癌中细胞周期蛋白E的表达进行免疫组化分析。63.2%的标本中存在cyclin E的过表达，且与透明细胞癌、低分化癌和浆液性癌相关（P
BACKGROUND. Cyclins, cyclin dependent kinases (cdks), and their inhibitors act in combination to regulate progression through the cell cycle and often are dysregu lated in carcinoma. The authors hypothesized that cyclin E plays an important role in ovarian carcinogenesis and that its overexpression may be an indicator of a poor prognosis.METHODS: Immunohistochemical analysis of cyclin E expression was performed by image analysis in normal ovaries, cystadenomas, tumors of low malignant potential, and 405 primary ovarian carcinomas by using tissue microarray technology.RESULTS: Overexpression of cyclin E was found in 63.2% of the samples and was associated with clear cell, poorly differentiated, and serous carcinoma (P