Sintering and concomitant crystallization of bioactive glasses
Sintering and concomitant crystallization of bioactive glasses
复制标题
DOI：
10.1111/ijag.13477
复制
发表时间：
2019-07-11
影响因子：
2.1
通讯作者：
Brauer, Delia S.
中科院分区：
文献类型：
--
作者：
Blaess, Carsten;Mueller, Ralf;Brauer, Delia S.
生物活性玻璃的烧结允许制备复杂的结构，如三维多孔支架。这种3D结构对于生物活性玻璃在骨再生中的临床应用特别有趣，因为支架可以作为生长中的骨细胞的向导，允许与现有和新形成的组织良好整合，同时支架缓慢降解。由于许多生物活性玻璃在热处理时明显倾向于结晶，3D支架在商业上还没有得到很大的开发。本文研究了结晶对几种生物活性玻璃烧结行为的影响。在一系列混合碱玻璃中，与生物玻璃45S5相比，CaO/碱金属氧化物比例的增加改善了烧结，而生物玻璃45S5的致密烧结受到抑制。添加少量氟化钙有助于保持较低的熔化和烧结温度。与玻璃13-93不同，这些新玻璃在烧结过程中结晶，但这并没有阻止致密化。生物活性玻璃颗粒大小的变化允许微调烧结过程产生的微孔隙度。
The sintering of bioactive glasses allows for the preparation of complex structures, such as three-dimensional porous scaffolds. Such 3D constructs are particularly interesting for clinical applications of bioactive glasses in bone regeneration, as the scaffolds can act as a guide for in-growing bone cells, allowing for good integration with existing and newly formed tissue while the scaffold slowly degrades. Owing to the pronounced tendency of many bioactive glasses to crystallize upon heat treatment, 3D scaffolds have not been much exploited commercially. Here, we investigate the influence of crystallization on the sintering behavior of several bioactive glasses. In a series of mixed-alkali glasses an increased CaO/alkali metal oxide ratio improved sintering compared to Bioglass 45S5, where dense sintering was inhibited. Addition of small amounts of calcium fluoride helped to keep melting and sintering temperatures low. Unlike glass 13-93, these new glasses crystallized during sintering but this did not prevent densification. Variation in bioactive glass particle size allowed for fine-tuning the microporosity resulting from the sintering process.