Atypical molecular profile for joint development in the avian costal joint.
Atypical molecular profile for joint development in the avian costal joint.
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鸟类肋关节关节发育的非典型分子特征。
DOI：
10.1002/dvdy.22388
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Burke,AC
中科院分区：
文献类型：
--
作者：
Winslow,BB;Burke,AC
滑膜关节的发育涉及软骨原基的生成、软骨原基之间的间带的形成以及间带的空化以产生充满液体的空腔。层间发育尚不完全清楚，但层间被认为是从成骨细胞发育而来，这些细胞受到包括 Wnt 和 Bmp 家族成员在内的一系列基因表达的级联抑制而进一步软骨形成。我们检查了很少研究的鸟类肋关节的发育，以更好地了解关节发育的机制。肋关节位于肋骨内，在形态上与跖趾关节相似，并且以相似的方式经历空化。与其他间带相比，肋关节间带中不存在 Wnt14/9a、Gdf5、Chordin、Barx1 和 Bapx1，这与活性 β-catenin 和磷酸化 Smad 1/5/8 的缺乏一致。然而，Autotaxin和Noggin被表达。肋关节的分子特征表明存在其他区域间发育机制。发育动力学 239:2547–2557, 2010。© 2010 Wiley-Liss, Inc.
Development of synovial joints involves generation of cartilaginous anlagen, formation of interzones between cartilage anlagen, and cavitation of interzones to produce fluid filled cavities. Interzone development is not fully understood, but interzones are thought to develop from skeletogenic cells that are inhibited from further chondrogenic development by a cascade of gene expression including Wnt and Bmp family members. We examined the development of the rarely studied avian costal joint to better understand mechanisms of joint development. The costal joint is found within ribs, is morphologically similar to the metatarsophalangeal joint, and undergoes cavitation in a similar manner. In contrast to other interzones,Wnt14/9a,Gdf5,Chordin,Barx1, andBapx1are absent from the costal joint interzone, consistent with the absence of active β‐catenin and phosphorylated Smad 1/5/8. HoweverAutotaxinandNogginare expressed. The molecular profile of the costal joint suggests there are alternative mechanisms of interzone development. Developmental Dynamics 239:2547–2557, 2010. © 2010 Wiley‐Liss, Inc.