REVERSAL OF MORPHINE DISRUPTION OF MATERNAL-BEHAVIOR BY CONCURRENT TREATMENT WITH THE OPIATE ANTAGONIST NALOXONE
REVERSAL OF MORPHINE DISRUPTION OF MATERNAL-BEHAVIOR BY CONCURRENT TREATMENT WITH THE OPIATE ANTAGONIST NALOXONE
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DOI：
10.1126/science.7123227
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
GRIMM, CT
中科院分区：
文献类型：
--
作者：
BRIDGES, RS;GRIMM, CT
在妊娠第17天通过手术终止妊娠的大鼠被注射吗啡、吗啡加盐酸纳洛酮或生理盐水，然后测试母亲对寄养后代的反应。单靠吗啡治疗就严重干扰了母体反应性的发生率和质量。同时给注射吗啡的大鼠注射纳洛酮可以恢复对寄养幼鼠的快速行为反应，因此同时注射吗啡和纳洛酮的大鼠的反应与注射生理盐水的对照组没有区别。吗啡的破坏性作用似乎并不是由于在野外装置中测得的活动水平普遍降低所致。大鼠母性行为的正常开始和维持可能受内源性阿片类药物的调节。
Rats whose pregnancies were surgically terminated on day 17 of gestation were injected with morphine, morphine plus naloxone hydrochloride, or saline, and then tested for maternal responsiveness toward foster young. Morphine treatment alone significantly disrupted the rate of onset and quality of maternal responsiveness. Concurrent administration of naloxone to morphine-injected rats reinstated the rapid onset of behavioral responsiveness toward foster young, such that the responsiveness of the rats treated with both morphine and naloxone was indistinguishable from that shown by saline-injected controls. The disruptive effects of morphine did not appear to result from a general reduction in activity levels as measured in an open-field apparatus. The normal onset and maintenance of maternal behavior in the rat may be regulated by endogenous opiates.