Antibacterial properties of nitric oxide-releasing sol-gels
Antibacterial properties of nitric oxide-releasing sol-gels
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DOI：
10.1002/jbm.a.20030
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发表时间：
2003-12-15
影响因子：
4.9
通讯作者：
Schoenfisch, MH
中科院分区：
文献类型：
--
作者：
Nablo, BJ;Schoenfisch, MH
介绍了释放一氧化氮（NO）溶胶-凝胶涂层的抗菌特性。从这些表面释放的NO在短时间内（约1小时）是稳定的，并在几天内可测量。通过将对照和释放NO的溶胶-凝胶暴露于约10（8）菌落形成单位（cfu）/mL的铜绿假单胞菌盐水悬浮液中来评价NO防止细菌粘附的能力。铜绿假单胞菌对溶胶-凝胶对照的粘附取决于溶胶-凝胶制剂。溶胶-凝胶表面能够NO释放减少细菌粘附30%至95%相对于控制。控制和NO-释放表面的接触角测量是相似的，支持NO作为抗细菌粘附的抗菌剂的作用。(C)2003 Wiley Periodicals，Inc.
The antibacterial characteristics of nitric oxide (NO)-releasing sol-gel coatings are described. The NO release from these surfaces is steady over short periods (approximate to1 h) and measurable over several days. The ability of NO to prevent bacterial adhesion is evaluated by exposing controls and NO-releasing sol-gels to approximate to10(8) colony-forming units (cfu)/mL saline suspensions of Pseudomonas aeruginosa. Pseudomonas aeruginosa adhesion to sol-gel controls varies depending on the sol-gel formulation. Sol-gel surfaces capable of NO release decrease bacterial adhesion by 30% to 95% relative to controls. The contact angle measurements of control and NO-releasing surfaces are similar, supporting NO's action as an antibacterial agent against bacterial adhesion. (C) 2003 Wiley Periodicals, Inc.