Reduction of Alzheimer’s Disease Amyloid β in plasma by hemodialysis and its relation to cognitive functions.
Reduction of Alzheimer’s Disease Amyloid β in plasma by hemodialysis and its relation to cognitive functions.
复制标题
血液透析减少阿尔茨海默病血浆中β淀粉样蛋白及其与认知功能的关系。
DOI：
10.1159/000322624
复制
发表时间：
2011
影响因子：
3
通讯作者：
Sugiyama S.
中科院分区：
文献类型：
--
作者：
Kitaguchi N.;Kawaguchi K.;Nakai S.;Murakami K.;Ito S.;Hoshino H.;Hori H.;Ohashi A.;Shimano Y.;Suzuki N.;Yuzawa Y.;Mutoh T.;Sugiyama S.
背景/目的通过血液净化快速去除血浆淀粉样蛋白（Aβ）可能作为阿尔茨海默病治疗的外周Aβ库。方法对37例血液透析患者进行血Aβ水平测定和简易精神状态检查（MMSE），并与对照组进行比较结果透析器对Aβ 1-40和Aβ 1-42的有效清除率分别为63.9±14.4和51.6±17.0%，导致全身循环中的Aβs分别减少51.1±8.9和32.7± 12.0%。虽然透析前血浆Aβs（Aβ 1-40为750.8± 171.3pg/ml）高于Alzheimer病患者，但血液透析患者的认知状态相对正常，尤其是透析时间较长的患者。反复快速降低血浆Aβs可维持认知状态。
Background/AimsRapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer’s disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states.MethodsAβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9±4.1 years).ResultsThe dialyzers effectively removed Aβ 1–40 and Aβ 1–42, 63.9±14.4 and 51.6±17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1±8.9 and 32.7±12.0%, respectively. Although the plasma Aβs before dialysis (750.8±171.3 pg/ml for Aβ 1–40) were higher than those reported for Alzheimer’s disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages.ConclusionsDialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state.