Lox6, a leech Dfd ortholog, is expressed in the central nervous system and in peripheral sensory structures.
Lox6, a leech Dfd ortholog, is expressed in the central nervous system and in peripheral sensory structures.
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Lox6 是水蛭 Dfd 直系同源物，在中枢神经系统和外周感觉结构中表达。
DOI：
10.1007/s004270050153
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Macagno,ER
中科院分区：
文献类型：
--
作者：
Wong,VY;Macagno,ER
对一个新分离到的含有Antp类同源框的水蛭cDNA进行序列分析，结果表明Lox6基因是果蝇Dfd基因的直系同源基因。原位杂交结果显示，Lox6在胚胎发育过程中主要表达于中枢神经系统和外周感觉系统，在从食管下神经节（RG2）到最后神经节的各个神经节中都能检测到Lox6 mRNA的表达，其中在RG3中的表达水平最高。在外周，Lox6主要在感觉器的原基和眼睛中表达。Lox6的这种表达模式表明其功能之一可能是促进神经元表型的多样化。
Sequence analysis of a newly isolatedHirudo medicinaliscDNA containing anAntennapedia(Antp)-class homeobox suggests that the corresponding gene,Lox6, is an ortholog of theDrosophilaDeformed(Dfd) gene. In situ hybridization of whole-mounted preparations shows that the major sites ofLox6expression during embryogenesis are the central nervous system (CNS) and the peripheral sensory system.Lox6mRNA can be detected in a subset of neurons in each ganglion from the subesophageal ganglion (RG2) to the most posterior ganglion, with the highest level of expression seen in RG3. Peripherally,Lox6is expressed principally in the primordia of the sensillae and in the eyes. This pattern of expression ofLox6suggests that one of its functions may be to contribute to the diversification of neuronal phenotypes.