Selective Mesoaccumbal Pathway Inactivation Affects Motivation but Not Reinforcement-Based Learning in Macaques
Selective Mesoaccumbal Pathway Inactivation Affects Motivation but Not Reinforcement-Based Learning in Macaques
复制标题
选择性中脑通路失活会影响猕猴的动机，但不会影响基于强化的学习
DOI：
10.1016/j.neuron.2020.07.013
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发表时间：
2020
期刊：
影响因子：
16.2
通讯作者：
Vanduffel Wim
中科院分区：
文献类型：
--
作者：
Vancraeyenest Pascaline;Arsenault John T.;Li Xiaolian;Zhu Qi;Kobayashi Kenta;Isa Kaoru;Isa Tadashi;Vanduffel Wim
啮齿类动物的研究已经证明了肠系膜神经回路在基于记忆的学习中的作用。然而，重要的是，虽然腹侧被盖区（VTA）的阶段性活动有助于强化学习，但啮齿动物的证据表明，紧张性VTA活动和相关的多巴胺释放的缓慢变化有助于调节动机行为。尽管如此，在灵长类动物中，还没有研究过动机和强化学习的中脑回路持续阻塞的后果。使用双重感染病毒载体技术，我们证明，选择性，单向性和可逆性阻断的主要多巴胺系膜回路在猴子增加网络水平的功能连接，特别是在额颞叶皮层。这些全球网络的变化与强化学习的缺陷在一个对象的歧视逆转任务。相比之下，持续的中脑失活大大降低了执行动机为基础的决策任务的动机。因此，灵长类动物的中脑神经通路对高努力动机至关重要，但对所有形式的基于学习的学习却并非如此。
Rodent studies have demonstrated the role of the mesoaccumbal circuit in reinforcement-based learning. Importantly, however, while phasic activity of the ventral tegmental area (VTA) contributes to reinforcement learning, rodent evidence suggests that slow changes in tonic VTA activity and associated accumbal dopamine release help regulate motivational behavior. Nonetheless, the consequences of sustained blockage of the mesoaccumbal circuit for motivation and reinforcement learning have not yet been examined in primates. Using a double-infection viral vector technique, we demonstrate that selective, unidirectional, and reversible blockage of the primarily dopaminergic mesoaccumbal circuit in monkeys increased network-level functional connectivity, especially in fronto-temporal cortex. These global network changes were not associated with deficits in reinforcement learning during an object discrimination reversal task. In contrast, sustained mesoaccumbal inactivation greatly reduced motivation for performing a motivation-based decision-making task. Thus, the mesoaccumbal pathway in primates is critical for high-effort motivation but not for all forms of reinforcement-based learning.