Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma.
Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma.
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Dectin-1预测透明细胞肾细胞癌患者术后不良预后
DOI：
10.1038/srep32657
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发表时间：
2016-09-07
影响因子：
4.6
通讯作者：
Guo J
中科院分区：
文献类型：
--
作者：
Xia Y;Liu L;Bai Q;Wang J;Xi W;Qu Y;Xiong Y;Long Q;Xu J;Guo J
Dectin-1是一种经典的模式识别受体，通过其广泛的配体结合功能和随后的细胞因子产生，被认为是免疫稳态和癌症免疫的重要调节因子。本研究的目的是通过免疫组织化学组织芯片评估dectin-1在290例肾透明细胞癌（ccRCC）患者中表达的临床意义。我们发现dectin-1主要在ccRCC细胞上表达，与其他几个在线数据库一致。Kaplan-Meier法显示dectin-1的高表达与患者的无复发生存期（RFS）和总生存期（OS）缩短相关（P均< 0.001）。在多变量分析中，肿瘤dectin-1表达与其他临床参数一起也被证实为患者生存的独立预后因素（RFS和OS P < 0.001）。在结合这些特征（包括肿瘤dectin-1表达）后，构建了两个列线图来预测ccRCC患者的RFS和OS（c指数分别为0.796和0.812），并且比现有的综合模型表现得更好（所有模型比较P< 0.001）。总之，肿瘤dectin-1高表达是ccRCC患者不良临床结局的独立预测因子。这种分子和已建立的列线图可能有助于临床医生在未来的决策和治疗的发展。
Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 patients with clear cell renal cell carcinoma (ccRCC) through immunohistochemistry on tissue microarrays. We found that dectin-1 was predominantly expressed on ccRCC cells, in accordance with several other online databases. Moreover, Kaplan-Meier method was conducted and high expression of tumoral dectin-1 was associated with shorter patient recurrence free survival (RFS) and overall survival (OS) (P < 0.001 for both). In multivariate analyses, tumoral dectin-1 expression was also confirmed as an independent prognostic factor for patients’ survival together with other clinical parameters (P < 0.001 for RFS and OS). After incorporating these characteristics including tumoral dectin-1 expression, two nomograms were constructed to predict ccRCC patients’ RFS and OS (c-index 0.796 and 0.812, respectively) and performed better than existed integrated models (P< 0.001 for all models comparisons). In conclusion, high tumoral dectin-1 expression was an independent predictor of adverse clinical outcome in ccRCC patients. This molecule and established nomograms might help clinicians in future decision making and therapeutic developments.
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影响因子：
7.7
作者：
Chiba S;Ikushima H;Ueki H;Yanai H;Kimura Y;Hangai S;Nishio J;Negishi H;Tamura T;Saijo S;Iwakura Y;Taniguchi T
通讯作者：
Taniguchi T
影响因子：
3.4
作者：
Volpe, Alessandro;Patard, Jean Jacques
通讯作者：
Patard, Jean Jacques
影响因子：
51.1
作者：
Ko, Jenny J.;Xie, Wanling;Heng, Daniel Y. C.
通讯作者：
Heng, Daniel Y. C.
Interleukin-11 受体可预测早期透明细胞肾细胞癌患者的术后临床结果。
影响因子：
2.4
作者：
Pan, Deng;Xu, Le;Gu, Jianxin
通讯作者：
Gu, Jianxin
影响因子：
4.8
作者：
Ariizumi, K;Shen, GL;Takashima, A
通讯作者：
Takashima, A