Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
复制标题
自分泌运动因子活性预测原发性硬化性胆管炎的无移植生存
DOI：
10.1038/s41598-019-44762-7
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发表时间：
2019
影响因子：
4.6
通讯作者：
Hov JR
中科院分区：
文献类型：
--
作者：
Dhillon AK;Kremer AE;Kummen M;Boberg KM;Elferink RPO;Karlsen TH;Beuers U;Vesterhus M;Hov JR
自分泌运动因子与肝脏疾病的严重程度和无移植存活率相关。本研究旨在验证自分泌运动因子作为挪威大导管PSC患者的两个队列（一个发现组（n= 165）和一个验证组（n= 87））中的生物标志物。自分泌运动因子的血清活性通过荧光酶测定法在稀释的血清中测量。达到终点肝移植或死亡的患者（发现组：n= 118 [71.5%];验证组：n= 35 [40.2%]）与其他患者相比，显示出更高的自分泌运动因子活性，分别为P< 0.001和P = 0.004。Kaplan-Meier生存分析显示，自分泌运动因子活性增加与无肝移植生存期缩短之间存在强相关性（发现组：P< 0.001，验证组：P= 0.001）。自分泌运动因子活性与炎症性肠病或肝胆恶性肿瘤的发生之间没有关系。在多变量分析中，高自分泌运动因子活性与肝移植或死亡风险增加相关（风险比2.03（95%置信区间1.21-3.40），P< 0.01），独立于马约风险评分、内部增强肝纤维化评分和血清白细胞介素-8。总之，血清自分泌运动因子活性增加与肝移植无存活率降低相关，与马约风险评分和炎症及纤维化标志物无关。
Autotaxin has been associated with liver disease severity and transplant-free survival. This study aimed to validate autotaxin as a biomarker in two cohorts of Norwegian large-duct PSC patients, one discovery panel (n= 165) and one validation panel (n= 87). Serum activity of autotaxin was measured in diluted sera by a fluorometric enzymatic assay. Patients reaching an end-point, liver transplantation or death, (discovery panel:n= 118 [71.5%]; validation panel:n= 35 [40.2%]), showed higher autotaxin activity compared with the other patients,P< 0.001 andP= 0.004, respectively. Kaplan-Meier survival analyses showed a strong association between increasing autotaxin activity and shorter liver transplant-free survival (discovery panel:P< 0.001, validation panel:P= 0.001). There was no relationship between autotaxin activity and the presence of inflammatory bowel disease or occurrence of hepatobiliary malignancy. In a multivariable analysis, high autotaxin activity was associated with an increased risk of liver transplantation or death (hazard ratio 2.03 (95% confidence interval 1.21–3.40),P< 0.01), independent from Mayo risk score, an in-house enhanced liver fibrosis score and interleukin-8 in serum. In conclusion, increased serum autotaxin activity is associated with reduced liver transplant-free survival independent from Mayo risk score and markers of inflammation and fibrosis.
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影响因子：
4.6
作者：
Wunsch E;Krawczyk M;Milkiewicz M;Trottier J;Barbier O;Neurath MF;Lammert F;Kremer AE;Milkiewicz P
通讯作者：
Milkiewicz P
影响因子：
3.7
作者：
Pleli T;Martin D;Kronenberger B;Brunner F;Köberle V;Grammatikos G;Farnik H;Martinez Y;Finkelmeier F;Labocha S;Ferreirós N;Zeuzem S;Piiper A;Waidmann O
通讯作者：
Waidmann O
影响因子：
25.7
作者：
Vesterhus, Mette;Holm, Anders;Lund-Johansen, Fridtjof
通讯作者：
Lund-Johansen, Fridtjof
影响因子：
8.9
作者：
W. R. Kim;T. Therneau;R. Wiesner;J. Poterucha;J. Benson;M. Malinchoc;N. LaRusso;K. Lindor;E. Dickson
通讯作者：
W. R. Kim;T. Therneau;R. Wiesner;J. Poterucha;J. Benson;M. Malinchoc;N. LaRusso;K. Lindor;E. Dickson
影响因子：
6
作者：
Kummen, Martin;Vesterhus, Mette;Hov, Johannes Roksund
通讯作者：
Hov, Johannes Roksund