Protein phase separation: A novel therapy for cancer?
Protein phase separation: A novel therapy for cancer?
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DOI：
10.1111/bph.15242
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发表时间：
2020-08
影响因子：
7.3
通讯作者：
Wei Wang;Ying-qian Chen;Aixiao Xu;Minyi Cai;Ji Cao;Hong Zhu;Bo Yang;Xuejing Shao;Meidan Ying-Me
中科院分区：
文献类型：
--
作者：
Wei Wang;Ying-qian Chen;Aixiao Xu;Minyi Cai;Ji Cao;Hong Zhu;Bo Yang;Xuejing Shao;Meidan Ying-Me
近年来，相分离在广泛的生物过程中起着举足轻重的作用。由于肿瘤与细胞内生理功能紊乱密切相关，发现细胞内调节的新机制已被视为肿瘤治疗的新方向。将相分离的概念引入疾病机制的复杂描述中可能会提供许多不同的见解。在此，我们回顾了癌症相关蛋白相分离的最新研究成果，描述了相分离与癌症相关关键蛋白之间可能的关系，并指出了可能的调节方式，特别是相分离的候选药物，这可能为癌症治疗提供更有效的策略。
In recent years, phase separation has been increasingly reported to play a pivotal role in a wide range of biological processes. Due to the close relationships between cancer and disorders in intracellular physiological function, the identification of new mechanisms involved in intracellular regulation has been regarded as a new direction for cancer therapy. Introducing the concept of phase separation into complex descriptions of disease mechanisms may provide many different insights. Here, we review the recent findings on the phase separation of cancer‐related proteins, describing the possible relationships between phase separation and key proteins associated with cancer and indicate possible regulatory modalities, especially drug candidates for phase separation, which may provide more effective strategies for cancer therapy.