Rheological and dynamical characterization of blood analogue flows in a slit
Rheological and dynamical characterization of blood analogue flows in a slit
复制标题
DOI：
10.1016/j.ijheatfluidflow.2013.12.008
复制
发表时间：
2014-04-01
影响因子：
2.6
通讯作者：
Semiao, Viriato
中科院分区：
文献类型：
--
作者：
Completo, Carlos;Geraldes, Vitor;Semiao, Viriato
血栓形成和溶血是血液破坏现象，取决于流体动力学，特别是剪应力。这项工作通过实验(使用微层技术)和数值(使用CFD)稳态牛顿(水和水/甘油溶液)流体流动和非牛顿(水/甘油/黄原胶)血液模拟流动来解决这个问题，狭缝高度为1.3 mm，宽度为30 mm。所得结果可为设计用于诊断和治疗的血液操作体外装置提供有用的信息。CFD计算结果表明，Herschel-Bulkley粘性模型的速度预测结果与Micro-PIV的实验数据吻合较好。粘度测量证明，水/甘油(35%w/w)/黄原胶(0.02%w/w)溶液很好地模拟了血液的整体粘度，在充分发展的流动中呈现出速度剖面形状，中心变平，这是剪切稀化流体的典型特征。在所研究的流速(6.7-25.3 L/小时)下，实验测得的模拟血液流动的最大剪应力(1.39-3.11Pa.)表明，由于红细胞、白细胞和血小板的溶血阈值分别为150pA、10pA和7.5pA，因此不太可能发生溶血。然而，由于切应力低于血栓/凝血阈值(1.0-1.8pa)，最小流速的情况可能会在血液循环中产生靠近壁面的血栓形成。(C)2013 Elsevier Inc.保留所有权利。
Thrombus formation and haemolysis are blood destructive phenomena depending on the flow hydrodynamics, particularly the shear stresses. This work addresses this issue by characterizing experimentally (using the micro-Ply technique) and numerically (using CFD) steady-state Newtonian (water and water/glycerine solutions) fluid flows and non-Newtonian (water/glycerine/xanthan) blood analogue flows, in a slit with a height of 1.3 mm and a width of 30 mm. The results obtained may provide useful information in the design of extracorporeal devices manipulating blood for diagnosis and therapeutics. Results from CFD showed that the Herschel-Bulkley viscosity model yields velocity predictions in excellent agreement with the experimental data obtained with the micro-PIV. Viscosity measurements evidenced that the water/glycerine (35% w/w)/xanthan (0.02% w/w) solution mimics well the blood global viscosity, exhibiting velocity profile shapes in fully developed flows flattened at the centre, typical of shear-thinning fluids. The maximum shear stresses obtained experimentally (1.39-3.11 Pa) for the blood analogue flows at the studied rates (6.7-25.3 L/h) evidence that haemolysis is unlikely to occur since lysis threshold values are 150 Pa for erythrocytes, 10 Pa for leucocytes and 7.5 Pa for platelets. However, the smallest flow rate cases may be of concern in blood circulation by yielding clot formation near the walls since the shear stresses there are bellow the thrombus/coagulation threshold (1.0-1.8 Pa). (C) 2013 Elsevier Inc. All rights reserved.