Chemical synthesis of a core 2 branched pentasaccharide containing a carboxylate group.
Chemical synthesis of a core 2 branched pentasaccharide containing a carboxylate group.
复制标题
含有羧酸根的核心 2 支链五糖的化学合成。
DOI：
10.1016/s0960-894x(00)00497-2
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发表时间：
2000
影响因子：
2.7
通讯作者：
Matta,KL
中科院分区：
文献类型：
--
作者：
Xia,J;Alderfer,JL;Matta,KL
设计并合成了一种新型受体9的6-羟基与(Fucα1–3)GlcNAcβ(1–6){3-[1-carboxymethyl]-Galβ(1–3)}GalNAcα–OMe给体10在NiS-TfOH催化下区域选择性偶联得到的具有半乳糖β(1-4)Gal TfOH序列的含羧酸盐的五糖碳化物1。
Design and synthesis of a carboxylate-containing pentasaccahride 1 with the Galβ(1–4) (Fucα1–3)GlcNAcβ(1–6){3-[1-carboxymethyl]-Galβ(1–3)}GalNAcα–OMe sequence, which is obtained through regioselective coupling of the 6-OH of a novel acceptor 9 with Lewisxdonor 10 catalyzed by NIS-TfOH are described.