A general model of coupled drug release and tissue absorption for drug delivery devices
A general model of coupled drug release and tissue absorption for drug delivery devices
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DOI：
10.1016/j.jconrel.2015.09.025
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发表时间：
2015-11-10
影响因子：
10.8
通讯作者：
Pontrelli, Giuseppe
中科院分区：
文献类型：
--
作者：
McGinty, Sean;Pontrelli, Giuseppe
在本文中，我们提出了一个一般模型的药物释放从药物输送装置和随后的运输在生物组织。该模型包括药物在聚合物涂层中的扩散、溶解和溶解度，以及在生物组织中的扩散、对流和反应。每一层包含结合和自由药物相，使所得到的模型是一个耦合的两相两层系统的偏微分方程。其中一个新颖之处是模型在每一层中的通用性。在药物涂层内，我们的模型包括扩散以及三种不同的溶解模型。我们表明，该模型也可用于溶解迅速或不相关的情况下，另外，当药物释放不受其溶解度的限制。在生物组织内，该模型可以考虑非线性饱和可逆结合，线性可逆结合和线性不可逆结合被恢复为特殊情况。我们的模型的一般性将允许模拟从广泛的药物输送装置，包括许多不同的应用程序的释放。为了证明我们的模型的有效性，我们模拟了动脉支架药物释放的特定应用的结果。(c)2015年，作者。由爱思唯尔公司出版
In this paper we present a general model of drug release from a drug delivery device and the subsequent transport in biological tissue. The model incorporates drug diffusion, dissolution and solubility in the polymer coating, coupled with diffusion, convection and reaction in the biological tissue. Each layer contains bound and free drug phases so that the resulting model is a coupled two-phase two-layer system of partial differential equations. One of the novelties is the generality of the model in each layer. Within the drug coating, our model includes diffusion as well as three different models of dissolution. We show that the model may also be used in cases where dissolution is rapid or not relevant, and additionally when drug release is not limited by its solubility. Within the biological tissue, the model can account for nonlinear saturable reversible binding, with linear reversible binding and linear irreversible binding being recovered as special cases. The generality of our model will allow the simulation of the release from a wide range of drug delivery devices encompassing many different applications. To demonstrate the efficacy of our model we simulate results for the particular application of drug release from arterial stents. (c) 2015 The Authors. Published by Elsevier B.V.