Ring-Opening Fluorination of Isoxazoles
Ring-Opening Fluorination of Isoxazoles
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DOI：
10.1021/acs.orglett.2c01149
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发表时间：
2022-05-06
期刊：
影响因子：
5.2
通讯作者：
Yamaguchi, Junichiro
中科院分区：
文献类型：
--
作者：
Komatsuda, Masaaki;Ohki, Hugo;Yamaguchi, Junichiro
异恶唑的开环氟化反应已经被开发出来。用亲电氟化剂（Selectfluor）处理异恶唑后，经氟化和脱质子化可得到叔氟化羰基化合物。该方法具有反应条件温和、官能团耐受性好、实验操作简便等特点。实验还证明了α-氟氰基酮的各种转化，得到了各种氟代化合物。
A ring-openingfluorination of isoxazoles has beendeveloped. Upon treatment of isoxazoles with an electrophilicfluorinating agent (Selectfluor),fluorination followed by deproto-nation leads to tertiaryfluorinated carbonyl compounds. Thismethod features mild reaction conditions, good functional grouptolerance, and a simple experimental procedure. Diverse trans-formations of the resulting alpha-fluorocyanoketones were alsodemonstrated, furnishing a variety offluorinated compounds.