EXPRESSION OF THE FC-GAMMA RECEPTOR ON LY-1+ LYMPHOCYTES-B
EXPRESSION OF THE FC-GAMMA RECEPTOR ON LY-1+ LYMPHOCYTES-B
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DOI：
10.1002/eji.1830170621
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发表时间：
1987-06-01
影响因子：
5.4
通讯作者：
CORLEY, RB
中科院分区：
文献类型：
--
作者：
DEXTER, CM;CORLEY, RB
在Ly-1+ B细胞和B细胞肿瘤上检测IgG Fc受体（FcR）分子的表达。在前B和成熟细胞B表型的代表性Ly-1+ B细胞淋巴瘤上发现FcR分子。在这些细胞分别分化为B细胞或抗体分泌细胞期间，FcR的表达没有改变。Ly-1+ B细胞以低频率（约100）被发现。2%），在正常小鼠的脾脏，并在腹腔中，他们的代表性更大。出生后Ly-1+ B细胞的频率下降，尽管它们的数量在两个器官中增加。这些Ly-1+ B细胞在整个个体发育过程中表达FcR分子。此外，在Ly-1+ B细胞上表达的FcR的量与在其“常规”（Ly-1-）B细胞对应物上表达的水平相似。在自身免疫小鼠的Ly-1+ B细胞上也发现了FcR。对Ly-1+ B细胞FcR分子表达的意义进行了讨论。
The expression of IgG Fc receptor (FcR) molecules was examined on Ly-1+ B cells and B cells tumors. FcR molecules were found on a representative Ly-1+ B cell lymphoma of the pre-B and as well as of the mature cell B phenotypes. The expression of the FcR did not change on these cells during their differentiation to B cells or to antibody-secreting cells, respectively. Ly-1+ B cells were found at low frequency (.apprx. 2%) in the spleens of normal mice, and in the peritoneal cavity where their representation was greater. The frequency of Ly-1+ B cells declined after birth, although their numbers increased in both organs. These Ly-1+ B cells expressed the FcR molecule throughout ontogeny. Furthermore, the amount of FcR expressed on Ly-1+ B cells was similar to the levels expressed on their "conventional" (Ly-1-) B cell counterparts. The FcR was aso found on Ly-1+ B cells from autoimmune mice. The significance of the expression of FcR molecules on Ly-1+ B cells is discussed.