Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study.
Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study.
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用透明质酸和纤维蛋白治疗的脚踝的骨软骨病变：一项单中心研究。
DOI：
10.3390/cells11040629
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发表时间：
2022-02-11
期刊：
影响因子：
6
通讯作者：
Makwana N
中科院分区：
文献类型：
--
作者：
Abas S;Kuiper JH;Roberts S;McCarthy H;Williams M;Bing A;Tins B;Makwana N
踝关节骨软骨缺陷症(OCD)越来越多地被认为是踝关节损伤的重要临床后果，如果不治疗，可能会导致骨性关节炎。这项回顾性队列研究的目的是评估一种一期治疗强迫症的方法，其基础是将骨髓抽提物(BMA)离心以产生骨髓浓缩物(BMC)。在双注射器中，浓缩物与凝血酶在一个注射器中混合，而透明质酸和纤维蛋白原在第二个注射器中混合。然后将这两种混合物注入并结合到准备好的缺陷中。在基线和此后每年收集临床结果和生活质量评分(MOXFQ和EQ-5D)。多水平模型用于分析分数随时间的变化规律。2015年至2020年期间，共有94名患者接受治疗。从基线到1年，MOXFQ的三个组成部分的平均值都有显著提高(P<；每个组成部分为0.001)，从1年到3年没有进一步的变化。EQ-5D指数也从基线到1年有显著的改善，没有进一步变化的证据。我们的结果有力地表明，这种BMC治疗对于脚踝强迫症患者来说是安全的，而且耐受性很好，无论是作为初级治疗的患者还是那些初级治疗失败的患者。这项技术为目前使用的软骨修复技术提供了一种安全、有效的替代方法，在36个月内具有良好的效果和低的并发症发生率。
Osteochondral defects of the ankle (OCD) are being increasingly identified as a clinically significant consequence of injury to the ankle, with the potential to lead to osteoarthritis if left untreated. The aim of this retrospective cohort study was to evaluate a single-stage treatment of OCD, based on bone marrow aspirate (BMA) centrifuged to produce bone marrow concentrate (BMC). In a dual syringe, the concentrate was mixed with thrombin in one syringe, whereas hyaluronan and fibrinogen were mixed in a second syringe. The two mixtures were then injected and combined into the prepared defect. Clinical outcome and quality of life scores (MOXFQ and EQ-5D) were collected at baseline and yearly thereafter. Multilevel models were used to analyse the pattern of scores over time. Ninety-four patients were treated between 2015 and 2020. The means of each of the three components of the MOXFQ significantly improved between baseline and 1 year (p < 0.001 for each component), with no further change from year 1 to year 3. The EQ-5D index also improved significantly from baseline to 1 year, with no evidence for further change. Our results strongly indicate that this BMC treatment is safe for, and well tolerated by, patients with OCD of the ankle as both primary treatment and those who have failed primary treatment. This technique provides a safe, efficacious alternative to currently employed cartilage repair techniques, with favourable outcomes and a low complication rate at 36 months.
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影响因子：
2.7
作者：
Corr, Daniel;Raikin, Jared;Raikin, Steven
通讯作者：
Raikin, Steven
DOI：
10.1053/jars.2003.50047
发表时间：
2003-04-01
影响因子：
4.7
作者：
Hunt, SA;Sherman, O
通讯作者：
Sherman, O
影响因子：
1.5
作者：
Johnson, Ben;Lever, Caroline;Makwana, Nilesh
通讯作者：
Makwana, Nilesh
影响因子：
4.8
作者：
Ferkel, Richard D.;Zanotti, Robert M.;Dopirak, Ryan M.
通讯作者：
Dopirak, Ryan M.
影响因子：
4.8
作者：
Lee, Keun-Bae;Bai, Long-Bin;Seon, Jong-Keun
通讯作者：
Seon, Jong-Keun