Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets.
Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets.
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DOI：
10.2174/1573404813666170921162041
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Osteen KG
中科院分区：
文献类型：
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作者：
Bruner-Tran KL;Mokshagundam S;Herington JL;Ding T;Osteen KG
虽然子宫内膜异位症在文献中首次被描述已经超过了世纪，但了解该疾病的病因和自然史一直具有挑战性。然而，广泛使用的小鼠和大鼠模型的实验性子宫内膜异位症已经能够阐明一些潜在的靶向过程，否则可能会促进这种疾病。 回顾利用啮齿类动物模型进行的各种研究，以说明其在检查与这种疾病的发展和进展相关的机制中的作用。 使用啮齿动物模型的子宫内膜异位症提供了一个更广泛的了解的风险因素的子宫内膜异位症的初步发展，细胞病理学的疾病和确定潜在的治疗目标。 虽然任何动物模型都有局限性，但已经开发的各种实验性子宫内膜异位症模型已经能够对这种疾病的许多方面进行调查。多亏了这些模型，我们对疾病发展的早期过程、类固醇反应性的作用、炎症过程和腹膜环境的理解得到了推进。最近的模型已经开始阐明表观遗传学改变如何影响这种疾病的分子基础以及困扰许多患者的多种合并症。对有助于阐明子宫内膜异位症发生机制的动物模型的持续研究为确定预防或逆转这种神秘疾病的治疗策略提供了最佳机会。
Although it has been more than a century since endometriosis was initially described in the literature, understanding the etiology and natural history of the disease has been challenging. However, the broad utility of murine and rat models of experimental endometriosis has enabled the elucidation of a number of potentially targetable processes which may otherwise promote this disease. To review a variety of studies utilizing rodent models of endometriosis to illustrate their utility in examining mechanisms associated with development and progression of this disease. Use of rodent models of endometriosis has provided a much broader understanding of the risk factors for the initial development of endometriosis, the cellular pathology of the disease and the identification of potential therapeutic targets. Although there are limitations with any animal model, the variety of experimental endometriosis models that have been developed has enabled investigation into numerous aspects of this disease. Thanks to these models, our under-standing of the early processes of disease development, the role of steroid responsiveness, inflammatory processes and the peritoneal environment has been advanced. More recent models have begun to shed light on how epigenetic alterations con-tribute to the molecular basis of this disease as well as the multiple comorbidities which plague many patients. Continued de-velopments of animal models which aid in unraveling the mechanisms of endometriosis development provide the best oppor-tunity to identify therapeutic strategies to prevent or regress this enigmatic disease.