On the use of the pion stopping distribution and the lesion additivity concept for the calculation of effective doses in pion treatment planning.
On the use of the pion stopping distribution and the lesion additivity concept for the calculation of effective doses in pion treatment planning.
复制标题
关于使用 π 停止分布和病变可加性概念计算 π 治疗计划中的有效剂量。
DOI：
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发表时间：
1990
影响因子：
3.5
通讯作者：
G. Lam
中科院分区：
文献类型：
--
作者：
G. Lam
LET 以及 RBE 的巨大空间变化是带电粒子束常规治疗计划制定的主要障碍之一。由于计划的生物效应分布无法针对每个患者进行实际测量，因此需要一种将效应与基本经验物理测量相关联的简单方案。对于π介子束的情况，高LET剂量分布与π介子停止密度相关，这可以使用多种技术间接测量。已经开发了基于这种空间相关性的方案。在该方法中，将局部剂量划分为高 LET 分数和低 LET 分数后，使用从最近对不同 LET 辐射混合物的放射生物学结果分析中提取的简单公式来计算局部有效剂量。这个简单的公式也可以从使用常见中间病变的可加性假设开发的混合辐射作用的机械模型中导出。本文将高LET剂量与π介子星之间的空间相关性概念与混合辐射的病灶可加性概念相结合，制定了一个简单的计算方案，用于计算π介子治疗计划中的有效剂量。类似的方案也可以针对其他带电粒子束开发。
The large spatial variation in LET, and hence in RBE, is one of the main obstacles in the development of routine treatment planning of charged particle beams. Since the biological effect distribution of plans cannot be realistically measured for each patient, a simple scheme of relating effect to basic empirical physical measurement is required. For the case of a pion beam, the high LET dose distribution is correlated with that of the pion stopping density, which can be indirectly measured using several techniques. A scheme based on this spatial correlation has been developed. In this method, after partitioning the local dose into a high and a low LET fraction, the local effective dose is computed using a simple formula extracted from a recent analysis of radiobiological results for mixtures of radiations of different LET. This simple formula can also be derived from a mechanistic model of mixed radiation action developed using the hypothesis of additivity of common intermediate lesions. In this paper, the concept of spatial correlation between the high LET dose and the pion stars is merged with the concept of lesion additivity for mixed radiation, from which a simple computational scheme is formulated for the calculation of effective doses in the treatment planning of pions. Similar schemes can also be developed for other charged particle beams.
影响因子：
3.4
作者：
CURTIS, SB
通讯作者：
CURTIS, SB