ESTRADIOL 16-ALPHA-HYDROXYLATION IN THE MOUSE CORRELATES WITH MAMMARY-TUMOR INCIDENCE AND PRESENCE OF MURINE MAMMARY-TUMOR VIRUS - A POSSIBLE MODEL FOR THE HORMONAL ETIOLOGY OF BREAST-CANCER IN HUMANS
ESTRADIOL 16-ALPHA-HYDROXYLATION IN THE MOUSE CORRELATES WITH MAMMARY-TUMOR INCIDENCE AND PRESENCE OF MURINE MAMMARY-TUMOR VIRUS - A POSSIBLE MODEL FOR THE HORMONAL ETIOLOGY OF BREAST-CANCER IN HUMANS
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DOI：
10.1073/pnas.82.18.6295
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
FISHMAN, J
中科院分区：
文献类型：
--
作者：
BRADLOW, HL;HERSHCOPF, RJ;FISHMAN, J
在这篇报告中，我们描述了我们关于雌二醇16. α之间关系的发现。-羟基化与乳腺肿瘤发病率的关系16-羟化酶在肿瘤高发菌株（如RIII和C3H）中升高，在癌症低发菌株（如C57BL）中降低，两者之间存在密切的相关性。反应的程度是高度可重复的，不受年龄或存在显性乳腺肿瘤的影响。雌二醇16. α的遗传研究。-羟化酶的研究表明，它是常染色体显性遗传，与雌二醇2-羟化酶或雄激素和黄体酮16 - α -羟化酶无关。此外，该反应在存在小鼠乳腺肿瘤病毒时明显增强，而在不存在病毒时则减弱。这些研究建立了遗传因素、激素因素和小鼠乳腺肿瘤病毒这三个乳腺肿瘤发生的关键因素之间的关系。
In this report, we describe our findings on the relationship between estradiol 16.alpha.-hydroxylation and mammary tumor incidence. A close correlation between the two has been demonstrated with 16-hydroxylase being elevated in strains with a high incidence of tumors, such as RIII and C3H, and low in strains with a low incidence of cancer, such as C57BL. The extent of reaction is highly reproducible and unaffected by age or presence of overt mammary tumors. Studies on the inheritance of estradiol 16.alpha.-hydroxylase showed that it is inherited as an autosomal dominant and is not correlated with estradiol 2-hydroxylase or androgen and progestin 16.alpha.-hydroxylases. In addition, the reaction was shown to be markedly enhanced by the presence of murine mammary tumor virus and diminished in the absence of the virus. These studies establish a relationship between genetics, hormonal factors, and murine mammary tumor virus, the three key factors in mammary tumorigenesis.