Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions.
Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions.
复制标题
DOI：
10.1186/s13059-018-1392-6
复制
发表时间：
2018-02-19
期刊：
影响因子：
12.3
通讯作者：
Krasileva KV
中科院分区：
文献类型：
--
作者：
Bailey PC;Schudoma C;Jackson W;Baggs E;Dagdas G;Haerty W;Moscou M;Krasileva KV
The plant immune system is innate and encoded in the germline. Using it efficiently, plants are capable of recognizing a diverse range of rapidly evolving pathogens. A recently described phenomenon shows that plant immune receptors are able to recognize pathogen effectors through the acquisition of exogenous protein domains from other plant genes. We show that plant immune receptors with integrated domains are distributed unevenly across their phylogeny in grasses. Using phylogenetic analysis, we uncover a major integration clade, whose members underwent repeated independent integration events producing diverse fusions. This clade is ancestral in grasses with members often found on syntenic chromosomes. Analyses of these fusion events reveals that homologous receptors can be fused to diverse domains. Furthermore, we discover a 43 amino acid long motif associated with this dominant integration clade which is located immediately upstream of the fusion site. Sequence analysis reveals that DNA transposition and/or ectopic recombination are the most likely mechanisms of formation for nucleotide binding leucine rich repeat proteins with integrated domains. The identification of this subclass of plant immune receptors that is naturally adapted to new domain integration will inform biotechnological approaches for generating synthetic receptors with novel pathogen “baits.” The online version of this article (10.1186/s13059-018-1392-6) contains supplementary material, which is available to authorized users.
登录
查看更多内容
DOI：
10.1126/science.1236011
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dangl JL;Horvath DM;Staskawicz BJ
通讯作者：
Staskawicz BJ
影响因子：
5.2
作者：
Costanzo, Stefano;Jia, Yulin
通讯作者：
Jia, Yulin
模因套件：用于发现和搜索的工具。
影响因子：
14.9
作者：
Bailey TL;Boden M;Buske FA;Frith M;Grant CE;Clementi L;Ren J;Li WW;Noble WS
通讯作者：
Noble WS
影响因子：
4.4
作者：
Copetti D;Zhang J;El Baidouri M;Gao D;Wang J;Barghini E;Cossu RM;Angelova A;Maldonado L CE;Roffler S;Ohyanagi H;Wicker T;Fan C;Zuccolo A;Chen M;Costa de Oliveira A;Han B;Henry R;Hsing YI;Kurata N;Wang W;Jackson SA;Panaud O;Wing RA
通讯作者：
Wing RA
影响因子：
64.5
作者：
Chae E;Bomblies K;Kim ST;Karelina D;Zaidem M;Ossowski S;Martín-Pizarro C;Laitinen RA;Rowan BA;Tenenboim H;Lechner S;Demar M;Habring-Müller A;Lanz C;Rätsch G;Weigel D
通讯作者：
Weigel D