Changes in cortical, cardiac, and respiratory activities in relation to spontaneous rhythmic jaw movements in ketamine‐anesthetized guinea pigs
Changes in cortical, cardiac, and respiratory activities in relation to spontaneous rhythmic jaw movements in ketamine‐anesthetized guinea pigs
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氯胺酮麻醉豚鼠皮层、心脏和呼吸活动与自发节律下颌运动相关的变化
DOI：
10.1111/eos.12817
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发表时间：
2021
影响因子：
1.9
通讯作者：
Kato Takafumi
中科院分区：
文献类型：
--
作者：
Yano Hiroshi;Matsuura Yutaka;Katagiri Ayano;Higashiyama Makoto;Toyoda Hiroki;Sato Hajime;Ueno Yoshio;Uzawa Narikazu;Yoshida Atsushi;Kato Takafumi
据报告，氯胺酮麻醉动物自发发生节律性下颌运动（RJM）。本研究调查了在补充氯胺酮注射后导致动物RJM发生的皮质、心脏和呼吸事件期间发生的生理过程。在氯胺酮-甲苯噻嗪麻醉下，准备14只豚鼠，以记录二腹肌的脑电图、心电图和肌电图活动，测量下颌运动和鼻呼气气流。在注射补充氯胺酮（12.5和25.0 mg kg-1，静脉注射）后23-29分钟，自发发生有节律的下颌运动和有节律的二腹肌收缩。两种氯胺酮剂量之间的RJM周期长度无显著差异（平均值±SD：12.5 mg kg-1，326.5 ± 60.0 ms; 25 mg kg-1，278.5 ± 45.1 ms）。注射氯胺酮后，二腹肌活动、心率和呼吸率以及皮质β功率显著降低，而皮质δ和θ功率显著增加。给予25.0 mg kg-1氯胺酮的动物的这些变化显著大于给予12.5 mg kg-1氯胺酮的动物。随着RJM的发生，这些变量的水平恢复到注射前水平，无论给予的氯胺酮剂量如何。这些结果表明，在补充氯胺酮注射后，自发RJM发生在氯胺酮药理作用消失的特定时期，这些RJM的特征是心脏、呼吸和皮质活动的典型变化。
It has been reported that rhythmic jaw movements (RJMs) spontaneously occur in ketamine‐anesthetized animals. The present study investigated the physiological processes that occur during the cortical, cardiac, and respiratory events which contribute to the genesis of RJMs in animals after supplemental ketamine injections. Fourteen guinea pigs were prepared to allow electroencephalographic, electrocardiographic, and electromyographic activities to be recorded from the digastric muscle, measurement of jaw movements, and nasal expiratory airflow under ketamine‐xylazine anesthesia. Rhythmic jaw movements spontaneously occurred with rhythmic digastric muscle contractions, 23–29 minutes after injection of supplemental ketamine (12.5 and 25.0 mg kg–1, intravenously). The cycle length of RJMs did not differ significantly between the two doses of ketamine (mean±SD: 12.5 mg kg–1, 326.5 ± 60.0 ms; 25 mg kg–1, 278.5 ± 45.1 ms). Following injection of ketamine, digastric muscle activity, heart and respiratory rates, and cortical beta power significantly decreased, while cortical delta and theta power significantly increased. These changes were significantly larger in animals given 25.0 mg kg–1of ketamine than in those given 12.5 mg kg–1. With the onset of RJMs, the levels of these variables returned to pre‐injection levels, regardless of the dose of ketamine administered. These results suggest that, following supplemental ketamine injections, spontaneous RJMs occur during a specific period when the pharmacological effects of ketamine wear off, and that these RJMs are characterized by stereotypical changes in cardiac, respiratory, and cortical activities.