Virus-mediated inhibition of the ppp(A2'p)nA system and its prevention by interferon.
Virus-mediated inhibition of the ppp(A2'p)nA system and its prevention by interferon.
复制标题
病毒介导的 ppp(A2p)nA 系统抑制及其干扰素的预防。
DOI：
10.1016/0006-291x(82)90647-7
复制
发表时间：
1982
影响因子：
3.1
通讯作者：
I. Kerr
中科院分区：
文献类型：
--
作者：
P. J. Cayley;M. Knight;I. Kerr
脑心肌炎病毒感染小鼠埃利希腹水瘤或L细胞或人HeLa细胞可抑制ppp（A2′p）nA依赖性核酸酶的活化，并阻止ppp（A2 ′p）nA的放射性类似物与ppp（A2 ′ p）nA结合蛋白的结合。这种ppp（A2′p）nA依赖性核酸酶响应病毒感染的丢失或失活可通过干扰素预处理细胞来防止。
Encephalomyocarditis virus infection of mouse Ehrlich ascites tumour or L-cells or human HeLa cells inhibits the activation of the ppp(A2′p)nA-dependent nuclease and prevents the binding of a radioactive analogue of ppp(A2′p)nA to the ppp(A2′p)nA binding protein. This loss or inactivation of the ppp(A2′p)nA-dependent nuclease in response to virus infection is prevented by interferon pretreatment of the cells.