Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration
Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration
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DOI：
10.1136/bjo.2005.076612
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发表时间：
2006-02-01
影响因子：
4.1
通讯作者：
Duker, JS
中科院分区：
文献类型：
--
作者：
Pieroni, CG;Witkin, AJ;Duker, JS
目的：描述非渗出型年龄相关性黄斑变性（AMD）的外观，采用高分辨率光学相干断层扫描（UHR-OCT）成像。方法：采用UHR-OCT眼科成像系统，利用飞秒激光光源，轴向分辨率为3 mm，获得非渗出型AMD患者的视网膜横截面图像。结果：42例（52只眼）临床诊断为非渗出性AMD的患者使用UHR-OCT系统进行了视网膜图像的观察研究。47/52只眼（90%）临床诊断为玻璃疣和/或视网膜色素上皮（RPE）改变。在这些患者中，UHR-OCT显示玻璃疣的三种模式：（1）明显的RPE赘生物，（2）RPE的锯齿状模式，以及（3）结节性玻璃疣。在UHR-OCT上，3只临床诊断为非渗出性AMD的眼睛（6%）有视网膜或RPE下液体的证据。这三个病人中有两个发现可疑的亚临床脉络膜新生血管的UHR-OCT.Conclusion：随着分辨率的增加UHR-OCT相比，标准OCT，视网膜外层的参与更清楚地定义。UHR-OCT可用于检测临床或血管造影无法观察到的早期渗出性变化。
Aim: To describe the appearance of the non-exudative forms of age related macular degeneration (AMD) as imaged by ultrahigh resolution optical coherence tomography (UHR-OCT).Methods: A UHR-OCT ophthalmic imaging system, which utilises a femtosecond laser light source capable of,3 mm axial resolution, was employed to obtain retinal cross sectional images of patients with non-exudative AMD. Observational studies of the resulting retinal images were performed.Results: 52 eyes of 42 patients with the clinical diagnosis of non-exudative AMD were imaged using the UHR-OCT system. 47 of the 52 (90%) eyes had the clinical diagnosis of drusen and/or retinal pigment epithelial (RPE) changes. In these patients, three patterns of drusen were apparent on UHR-OCT: (1) distinct RPE excrescences, (2) a saw toothed pattern of the RPE, and (3) nodular drusen. On UHR-OCT, three eyes (6%) with a clinical diagnosis of non-exudative AMD had evidence of fluid under the retina or RPE. Two of these three patients had findings suspicious for subclinical choroidal neovascularisation on UHR-OCT.Conclusion: With the increased resolution of UHR-OCT compared to standard OCT, the involvement of the outer retinal layers are more clearly defined. UHR-OCT may allow for the detection of early exudative changes not visible clinically or by angiography.